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>> Aug Vol. 32, No 4, 2017
Virologica Sinica publishes peer-reviewed original research articles and reviews concerning the latest developments in all branches of virology, including the research on the viruses of animals, plants and microbes. The journal welcomes studies on viruses as well as on viral infections and diseases. The journal will feature articles on new virus discovery, molecular characterization of viruses, viral pathogenesis and host immunity, vaccine development, antiviral ...   (read more)
Global visibility, available in Springer and covered by PubMed/Medline
Rapid peer review and online publishing (approximately 3 weeks)
Official journal of the Chinese Society for Microbiology
No page/color charges, open-access options
Free language editing
ISSN: 1674-0769
EISSN: 1995-820X
CN: 42-1760/Q
Research Article( Advanced Online Publication)
HIV-1-specific cytotoxic T lymphocytes (CTLs) and neutralizing antibodies (NAbs) are present during chronic infection,but the relative contributions of these effector mechanisms to viral containment remain unclear.Here,using an in vitro model involving autologous CD4+ T cells ..., Abstract
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Letter ( Advanced Online Publication)
Q3G is a natural derivative of quercetin and is already widely used in various foods and drinks.Our results clearly demonstrated that Q3G exerts antiviral activity against ZIKV in both tissue culture and knockout mice, and that post-exposure in vivo treatment with Q3G could have a beneficial ..., Abstract
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Letter ( Advanced Online Publication)
In this study, we improved the most commonly used methods for MS detection of SUMOylated sites and used an E. coli recombination SUMOylation system with SUMO-1 (T95R). This system provides fast enrichment of SUMOylated viral protein in less than 2 days, and shows advantage over the method of ..., Abstract
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Research Article( Advanced Online Publication)
Skin-resident dendritic cells (DCs) likely encounter incoming viruses in the first place,and their migration to lymph nodes following virus capture may promote viral replication.However,the molecular mechanisms underlying these processes remain unclear.In the present study,we found that compared to ..., Abstract
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Letter ( Advanced Online Publication)
In summary, we show here that HCV infection is associated with an upregulation of ARF4, which promotes HCV replication. Upon HCV infection, CREB3 was redistributed to nucleus and activated ARF4 transcription.Our studies demonstrate a host factor ARF4 upregulated in HCV replication, which may ..., Abstract
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Research Article
Innate immunity provides immediate defense against viral infection.Influenza A virus (IAV) is able to get past the first line of defense.Elucidation of the molecular interaction between influenza factors and the newly recognized host players in the innate response might help in our understanding of ..., Abstract
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Research Article
Little is known about the prevalence of drug-resistant mutations in HIV-1-positive individuals in Suzhou,China.To elucidate the transmitted drug resistance (TDR) and acquired drug resistance mutation (ADR) profiles,we collected blood specimens from 127 drug-naïve and 117 first-line drugtreated ..., Abstract
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Research Article
Human endogenous retrovirus W family (HERV-W) envelope (env) has been reported to be related to several human diseases,including autoimmune disorders,and it could activate innate immunity. However,there are no reports investigating whether human leukemia antigen (HLA)-A*0201+ restriction ..., Abstract
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Research Article
Diverse species of rodents and shrews,which are abundant worldwide,harbor a variety of viruses; some of these are closely related to human viruses and possess zoonotic potential.Previously studies have demonstrated that the mammarenavirus and hantavirus carried by rodents or shrews could cause ..., Abstract
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Research Article
The emergence of highly virulent porcine epidemic diarrhea virus (PEDV) variants in China caused huge economic losses in 2010.Since then,large-scale sporadic outbreaks of PED caused by PEDV variants have occasionally occurred in China.However,the molecular diversity and epidemiology of PEDV in ..., Abstract
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Research Article
Since 2010,variant strains of porcine epidemic diarrhea virus (PEDV) have caused disasters in the pork industry.The spike (S) protein,as the major immunity-eliciting antigen,has previously been used for serological testing and has been found to correlate significantly with the results of the serum ..., Abstract
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Research Article
Rabies remains a public health threat that kills approximately 59,000 people worldwide each year, most of which are from the developing countries of Africa and Asia where dog rabies are endemic. Therefore,developing an affordable and efficacious vaccine is crucial for rabies control in these ..., Abstract
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Letter
As a major protein of cypovirus capsid shell,VP5 performs as the clamp protein to stabilize the capsid shell structure (Yu et al.,2008).And as a part of viral RNA (vRNA) replication machinery,VP5 has been found to possess an ATP-independent RNA chaperoning activity (Yang et al.,2014).Here,we report ..., Abstract
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Letter
Taken together,we have successfully utilized the HDV ribozyme in the preparation of homogeneous RNA sample that may be free of sequence limitation at the 3'-end.To make the HDV approach-derived RNA suitable for directing de novo RNA synthesis by the WNV NS5 RdRP, the 2',3'-cyclic phosphate at its ..., Abstract
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Letter
In the present study,we used polyclonal antibodies (pAb) raised against SsRV and monoclonal antibodies (mAb) specific for the SsRV capsid protein p29 to successfully develop a rapid and simple immunochromatographic strip for the facile detection of SsRV., Abstract
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Letter
In conclusion,we first found that HIV infection upregulates the ATL1 mRNA.Up-regulation of ATL1 contributes to HIV-1 replication and down-regulation of ATL1 in host cells inhibited the viral replication.The further research found that ATL1 promoted the level of Env expression on the cell surface ..., Abstract
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Letter
In summary,the present study demonstrates that the forces favoring intra-animal diversification can cause the emergence of variants that,benefiting of their diversity at the population level,are able to succeed and spread in an often highly homogeneous environment,and to be further selected later., Abstract
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