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Virologica Sinica is an academic journal which aims at presenting the cutting-edge basic and applied research on viruses all over the world. The journal publishes peer-reviewed original research articles and reviews, as well as commentaries and letters to the editor, to encompass the latest developments in all branches of virology, including research on animal, plant and microbe viruses. The journal welcomes articles on virus discovery, viral pathogenesis...   (read more)
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ISSN: 1674-0769
EISSN: 1995-820X
CN: 42-1760/Q
2017 Impact Factor 2.415*
*2017 Journal Citation Reports
Perspective
Influenza is one of the oldest infectious diseases affecting humans. Every influenza pandemic in history has ended with disastrous outcomes regarding public health and the social economy. This year marks the 100th anniversary of the Spanish flu (H1N1) outbreak of 1918, which is recognized as ..., Abstract
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Perspective
The 2018 Medicine Nobel Prize was awarded jointly to two immunologists, James P. Allison at the University of Texas MD Anderson Cancer Center in Houston and Tasuku Honjo at Kyoto University in Japan, who pioneered a new way to treat cancers (Ledford et al. 2018). Both Laureates have ..., Abstract
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Review
Peste des petits ruminants (PPR) is a highly contagious transboundary animal disease with a severe socio-economic impact on the livestock industry, particularly in poor countries where it is endemic. Full understanding of PPR virus (PPRV) pathobiology and molecular biology is critical for ..., Abstract
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Research Article
We describe the first genome isolation of Middle East respiratory syndrome coronavirus (MERS-CoV) in Kenya. This fatal zoonotic pathogen was first described in the Kingdom of Saudi Arabia in 2012. Epidemiological and molecular evidence revealed zoonotic transmission from camels to humans and ..., Abstract
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Research Article
The major difficulties of human papillomavirus (HPV) treatment are its persistence and recurrence. The HPV E7 oncoprotein-loaded dendritic cells have been evaluated as cellular vaccine in previous reports. Plasmacytoid dendritic cells (pDCs) play an essential role of connecting the innate immune ..., Abstract
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Research Article
The development of a vaccine based on human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) that elicits potent protective antibodies against infection has been challenging. Recently, we compared the antibody production patterns of HIV-1 Env gp120 and hepatitis B virus surface ..., Abstract
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Research Article
Japanese encephalitis virus (JEV) is a mosquito-borne virus and the major cause of viral encephalitis in Asia. NS1', a 52-amino acid C-terminal extension of NS1, is generated with a -1 programmed ribosomal frameshift and is only present in members of the Japanese encephalitis serogroup of ..., Abstract
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Research Article
Porcine reproductive and respiratory syndrome (PRRS) continues to be one of the most important swine diseases worldwide. Interferon-c (IFNγ)-mediated type I cell-mediated immune response plays an important role in protection from, and clearance of, PRRS virus (PRRSV). Several lymphocyte subsets ..., Abstract
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Research Article
Mutations in the polymerase basic 2 (PB2) gene of avian influenza viruses are important signatures for their adaptation to mammalian hosts. Various adaptive mutations have been identified around the 627 and nuclear localization sequence (NLS) domains of PB2 protein, and these mutations ..., Abstract
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Research Article
2',3'-dideoxyguanosine (DoG) has been demonstrated to inhibit duck hepatitis B virus (DHBV) replication in vivo in a duck model of HBV infection. In the current study, the in vitro antiviral effects of DoG on human and animal hepadnaviruses were investigated. Our results showed that ..., Abstract
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Research Article
Dengue virus (DENV) and Zika virus (ZIKV) have spread throughout many countries in the developing world and infect millions of people every year, causing severe harm to human health and the economy. Unfortunately, there are few effective vaccines and therapies available against these viruses. ..., Abstract
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Letter
RNA virus features the high per-generation mutation rate, and thus usually exists as a population presenting intrahost diversity. By the aids of deep sequencing and bioinformatic techniques, recent studies have provided new insights into viral intrahost evolution and viral-host interaction. ..., Abstract
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Letter
An investigation was carried out to test for mink circovirus (MiCV) infection in samples from minks, foxes and raccoon dogs with diarrhea in China. The results demonstrated that the infection rates of MiCV in minks, foxes and raccoon dogs were very high on some fur farms in China. The fox was the ..., Abstract
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