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Virologica Sinica, 23 (6) : 406-415, 2008
Nuclear Egress of Herpesviruses*
Department of Microbiology, University of Iowa, BSB 3-432, Iowa City, IA 52242, USA
Herpesviruses assemble and fill their capsids in the infected cell nucleus, and must then move this enormous macromolecular assembly across the nuclear membrane and into the cytoplasm. Doing so is a complex, multi-step process that involves envelopment of the capsid at the inner nuclear membrane and de-envelopment by fusion with the outer nuclear membrane. This process is orchestrated by viral proteins, but requires the modification of cellular structures and mechanisms including the nuclear lamina. In this review I summarize recent research on the mechanism of nuclear envelopment and the viral and cellular systems involved in its execution.
  Published online: 5 Dec 2008
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