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Issue of Virologica Sinica
Global HIV-1 sequence Patterns. The complexity of HIV-1 epidemiology in different areas of the world leaves unique footprints. Interestingly, the underlying significant patterns of global HIV-1 genomes could be detected using suitable data mining methods. Signature patterns of Env gene on characteristic amino acids are inferred from four HIV-1 pandemic regions and three primary subtypes worldwide. After cross-validation of these patterns, geographical and evolutionary associations were deduced. The significant pattern at position 21 indicates both the association of glycine, leucine and isoleucine with Africa and the Southern Africa, United States, Southeast Asia and China, and the association with subtypes C, B and CRF01_AE. It is expected that these patterns could provide a valuable reference for the epidemiological research or the design of vaccines in HIV studies.??Cover designed by Meng Wang, Wuhan IOV)
Article List:
Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic viral infection that is a serious threat to humans. The disease is widely distributed in Africa, Asia, and Europe and has developed into a serious public health concern. Humans become infected through the bites of ticks, by contact with a patient ..., Abstract
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Research Article
The construction of the first infectious clone JFH-1 speeds up the research on hepatitis C virus (HCV). However, Huh7 cell line was the only highly permissive cell line for HCV infection and only a few clones were fully permissive. In this study, two different fully permissive clones of Huh7 cells ..., Abstract
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Research Article
Tripartite motif containing 22 (TRIM22), a member of the TRIM/RBCC family, has been reported to activate the nuclear factor-kappa B (NF-κB) pathway in unstimulated macrophage cell lines, but the detailed mechanisms governing this activation remains unclear. We investigated this mechanism in ..., Abstract
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Research Article
Hepatitis B virus (HBV) biosynthesis is primarily restricted to hepatocytes due to the governing of liver-enriched nuclear receptors (NRs) on viral RNA synthesis. The liver-enriched NR hepatocyte nuclear factor 4α (HNF4α), the key regulator of genes implicated in hepatic glucose metabolism, is ..., Abstract
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Research Article
The World Health Organization (WHO) standard assay for determining levels of the rabies virus neutralization antibody (RVNA) is the rapid fluorescent focus inhibition test (RFFIT), which is used to evaluate the immunity effect after vaccination against rabies. For RFFIT, CVS-11 was used as the ..., Abstract
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Research Article
The epidemiology of HIV-1 varies in different areas of the world, and it is possible that this complexity may leave unique footprints in the viral genome. Thus, we attempted to find significant patterns in global HIV-1 genome sequences. By applying the rule inference algorithm RIPPER (Repeated ..., Abstract
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Camelpox is an infectious skin disease of camels caused by camelpox virus (CMLV). It is confined to camel rearing belts of developing countries (Wernery U, et al., 2002). CMLV is classified in the Orthopoxvirus (OPV) genus of the subfamily Chordopoxvirinae in the Poxviridae family., Abstract
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The HIV-1 infection in humans has now become a pandemic and in the absence of treatment it often leads to acquired immunodeficiency syndrome (AIDS). Although significant progress has been made to reduce the HIV-1 viral load in the blood of infected patients, challenges still exist in areas such as ..., Abstract
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Meeting Announcement
The 10th academic symposium of Chinese Society for Virology (CSV) will be held on September 23-25, 2013, in Harbin, China, with the local host of Harbin Veterinary Research Institute, CAAS. The symposiums of CSV are held every other year in different cities across China, and cover the latest ..., Abstract
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