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Issue of Virologica Sinica
A special topic section on Structural Virology is included in this issue. The section contains three review articles, which cover the recent research advancement on the structures of reovirus particle, flavivirus NS2B-NS3 protease, and enterophage T7 RNA polymerase. The issue cover presents: i) Crystal structure of a late initiation complex of T7 RNA Polymerase; ii) Crystal structure of the NS2B-NS3 protease with a peptide-based inhibitor; iii) Cryo-EM structure of the turreted reovirus core. (Organizer of the special topic: Peng Gong, PhD. Wuhan Institute of Virology, Chinese Academy of Sciences.)
Article List:
Recently, the team led by Dr. Zhengli Shi from Wuhan Institute of Virology, Chinese Academy of Sciences, and Dr. Peter Daszak from Ecohealth Alliance identified SL-CoVs in Chinese horseshoe bats that were 95% identical to human SARS-CoV and were able to use human angiotensin-converting enzyme 2 ..., Abstract
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Viruses in the family Reoviridae are non-enveloped particles comprising a segmented double-stranded RNA genome surrounded by a two-layered or multi-layered icosahedral protein capsid. These viruses are classified into two sub-families based on their particle structural organization. Recent studies ..., Abstract
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Many flaviviruses are significant human pathogens causing considerable disease burdens, including encephalitis and hemorrhagic fever, in the regions in which they are endemic. A paucity of treatments for flaviviral infections has driven interest in drug development targeting proteins essential to ..., Abstract
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During transcription initiation, RNA polymerase binds tightly to the promoter DNA defining the start of transcription, transcribes comparatively slowly, and frequently releases short transcripts (3-8 nucleotides) in a process called abortive cycling. Transitioning to elongation, the second phase of ..., Abstract
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Herpes simplex virus-1 (HSV-1) is a major pathogen that causes various central nervous system (CNS) diseases, including herpes simplex encephalitis and meningitis. According to recent studies, PNKP significantly affects the proliferation of HSV-1 in astrocytes. Here, we used viral proliferation ..., Abstract
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In this study, we have investigated the antiviral activity of GuiQi polysaccharides (GQP) upon enterovirus 71 (EV71) in vitro. An assay using methyl thiazolyl tetrazolium (MTT), and analyses of cytopathic effects (CPE) were used to examine the antiviral activity of GQP upon Vero cells infected with ..., Abstract
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P74 is a per os infectivity factor of baculovirus. Here, we report the production of three monoclonal antibodies (mAbs), denoted as 20D9, 20F9 and 21E1, raised against P74 of Helicoverpa armigera nucleopolyhedrovirus (HearNPV), and the identification of their recognition epitopes. The full-length ..., Abstract
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This article has been retracted at the request of the Editor-in-Chief, as it contains large portions of text that have been duplicated from "Phylogenetic analysis of the non-structural (NS) gene of influenza A viruses isolated from mallards in Northern Europe in 2005" published in Virology Journal ..., Abstract
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