Virologica Sinica, 28 (6) : 315-317, 2013
Comment
Bats as Animal Reservoirs for the SARS Coronavirus:Hypothesis Proved After 10 Years of Virus Hunting
State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
 Correspondence: huzh@wh.iov.cn
(344.66KB)  
Abstract
Recently, the team led by Dr. Zhengli Shi from Wuhan Institute of Virology, Chinese Academy of Sciences, and Dr. Peter Daszak from Ecohealth Alliance identified SL-CoVs in Chinese horseshoe bats that were 95% identical to human SARS-CoV and were able to use human angiotensin-converting enzyme 2 (ACE2) receptor for docking and entry. Remarkably, they isolated the first known live bat SL-CoV that replicates in human and related cells. Their findings provide clear evidence that some SL-CoVs circulating in bats are capable of infecting and replicating in human (Ge X Y, et al., 2013).
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Received: 31 Oct 2013  Accepted: 28 Oct 2013  Published online: 3 Dec 2013
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