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Issue of Virologica Sinica
The H7N9 subtype of avian influenza A virus was for the first time found to infect humans since the outbreaks in March 2013 in China. Concerns about its risk on human public health rises, and the mechanisms of pathogenesis and host immunity are studied. The ultra-structure of H7N9 virus infections is characterized, and reported in this issue. Viruses were grown in Madin-Darby canine kidney (MDCK) cells and human lung explants tissues, and morphogenesis features of viral replication were examined by electron microscopy. The cover depicts virus particles budding/releasing in alveolar space and an induced sieve-like structure in the cytoplasm.
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Flaviviruses are positive-sense RNA viruses, and many are important human pathogens. Nonstructural protein 2B and 3 of the flaviviruses (NS2BNS3) form an endoplasmic reticulum (ER) membraneassociated hetero-dimeric complex through the NS2B transmembrane region. The NS2BNS3 complex is ..., Abstract
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Research Article
The double-shelled grass carp reovirus (GCRV) is capable of endogenous RNA transcription and processing. Genome sequence analysis has revealed that the protein VP2, encoded by gene segment 2 (S2), is the putative RNA-dependent RNA polymerase (RdRp). In previous work, we have ex-pressed the ..., Abstract
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Research Article
The biological features of most foamy viruses (FVs) are poorly understood, including bovine foamy virus (BFV). BFV strain 3026 (BFV3026) was isolated from the peripheral blood mononuclear cells of an infected cow in Zhangjiakou, China. A full-length genomic clone of BFV3026 was obtained from ..., Abstract
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Research Article
Infection by foot-and-mouth disease virus (FMDV) is triggered by the acidic pH in endosomes after virus uptake by receptor-mediated endocytosis. However, dissociation of the FMDV 146S particle in mildly acidic conditions renders inactivated foot-and-mouth disease (FMD) vaccines much less effective. ..., Abstract
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Research Article
Torque teno virus (TTV) has been found to be prevalent world-wide in healthy populations and in patients with various diseases, but its etiological role has not yet been determined. Using highthroughput unbiased sequencing to screen for viruses in the serum of a patient with persistent high fever ..., Abstract
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