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Issue of Virologica Sinica
Recent studies have found that viruses can subvert the host actin cytoskeletal system for efficacious infection, and actin dynamics facilitate many stages of viral infection, including virus binding, entry, nuclear localization, genomic transcription and reverse transcription, assembly, and egress/dissemination. In this issue, Spear and Wu have provided a comprehensive review on the close interactions of viruses with cellular F-actin during viral infection. The cover image shows the structured illumination microscopy (SIM) of actin filaments and the nucleus of Madin-Darby canine kidney (MDCK) cells (pseudo-colored in vibrant green), while the superimposed orange dots are added to the actin background to illustrate intracellular subviral particles. (The MDCK actin background image was provided by the courtesy of Dr. Ding Gao, from the Core Facility Center of Wuhan Institute of Virology.)
Article List:
As a fundamental component of the host cellular cytoskeleton, actin is routinely engaged by infecting viruses. Furthermore, viruses from diverse groups, and infecting diverse hosts, have convergently evolved an array of mechanisms for manipulating the actin cytoskeleton for efficacious infection. ..., Abstract
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Research Article
Sweepovirus is an important monopartite begomovirus that infects plants of the genus Ipomoea worldwide. Development of artificial infection methods for sweepovirus using agroinoculation is a highly efficient means of studying infectivity in sweet potato. Unlike other begomoviruses, it has ..., Abstract
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Research Article
Tobacco mosaic virus (TMV) causes significant yield loss in susceptible crops irrigated with contaminated water. However, detection of TMV in water is difficult owing to extremely low concentrations of the virus. Here, we developed a simple method for the detection and quantifi cation of TMV in ..., Abstract
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Research Article
Dengue virus (DENV) nonstructural protein 1 (NS1) is a highly conserved 46-kDa protein that contains 2 glycosylation sites (Asn-130 and Asn-207) and 12 conserved cysteine (Cys) residues. Here, we performed site-directed mutagenesis to generate systematic mutants of viral strain TSV01. The results ..., Abstract
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Research Article
A novel avian influenza A (H7N9) virus recently emerged in the Yangtze River delta and caused diseases, often severe, in over 130 people. This H7N9 virus appeared to infect humans with greater ease than previous avian infl uenza virus subtypes such as H5N1 and H9N2. While there are other potential ..., Abstract
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Research Article
VC2002, isolated from postweaning multisystemic wasting syndrome (PMWS)-affected pig, is a mixture of two porcine circovirus genotype 2b (PCV2b) viruses, K2 and K39. Preliminary experiments disclosed short-term adverse effects of K39, but not K2, on porcine foetuses. These findings led to the ..., Abstract
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Research Article
In the present study, 89 porcine reproductive and respiratory syndrome virus (PRRSV) isolates in China during 2007 to 2012 were randomly selected from the GenBank genetic sequence database. Evolutionary characteristics of these isolates were analyzed based on the sequences of non-structural protein ..., Abstract
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