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Issue of Virologica Sinica
Labeling of virus particles facilitates the study of early events in virus infection.In this issue, Ilyushina and collogues have provided a new and effective approach to label infl uenza viruses. The Function-Spacer-Lipid (FSL) constructs labeling with fluorescent (fluo-Ad-DOPE) or biotin-labeled (biot-CMG2-DOPE) probes were gently inserted into the membrane of seven human/avian Infl uenza viruses, and each virion contained several thousand copies of lipid probes. Virus infectivity and viral affi nity to sialyl receptors were tested and found not much affected in vitro. This lipid labeling approach provides a useful tool in the studies of virus attachment, virus endocytosis, intracellular traffi cking, and more. The cover image shows the transmission electron microscope (TEM) image of influenza viruses (pseudo-colored in indigo), and one virion in the middle labeled with the lipid construct is illustrated (pseudo-colored in fluorescent green). (The original TEM image was provided by the courtesy of Dr. Ding Gao, from the Core Facility Center of Wuhan Institute of Virology.)
Article List:
Research Article
Direct labeling of virus particles is a powerful tool for the visualization of virus-cell interaction events. However, this technique involves the chemical modification of viral proteins that affects viral biological properties. Here we describe an alternative approach of influenza virus labeling ..., Abstract
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Research Article
Rotavirus diarrhea is a major worldwide cause of infantile gastroenteritis; however, the mechanism responsible for intestinal fluid loss remains unclear. Water transfer across the intestinal epithelial membrane seems to occur because of aquaporins (AQPs). Accumulating evidence indicates that ..., Abstract
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Research Article
New strategies in vaccine development are urgently needed to combat emerging influenza viruses and to reduce the risk of pandemic disease surfacing. Being conserved, the M2e protein, is a potential candidate for universal vaccine development against influenza A viruses. Mycobacterium tuberculosis ..., Abstract
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Research Article
Prion diseases are a group of neurodegenerative diseases that are fatal. The study of these unique diseases in China is hampered by a lack of resources. Amongst the most important resources for biological study are monoclonal antibodies. Here, we characterize a panel of monoclonal antibodies ..., Abstract
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Research Article
Little information is available on the prevalence of drug-resistance mutations in patients harboring the human immunodeficiency virus type 1 (HIV-1) circulating recombinant form (CRF)07_BC variant in Sichuan, China. This study examined 375 plasma samples from patients with HIV-1 who were infected ..., Abstract
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Research Article
Porcine respiratory disease complex (PRDC) is a serious health problem that mainly affects growing and finishing pigs. PRDC is caused by a combination of viral and bacterial agents, such as porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza virus (SIV), Mycoplasma ..., Abstract
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Research Article
The effect of chitosan on the development of infection caused by Tobacco mosaic virus (TMV) in leaves of Nicotiana tabacum L. cv. Samsun has been studied. It was shown that the infectivity and viral coat protein content in leaves inoculated with a mixture of TMV (2 μg/mL) and chitosan (1 mg/mL) ..., Abstract
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