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Issue of Virologica Sinica
Varicella zoster virus (VZV) causes varicella (chicken pox) and herpes zoster (shingles). The current varicella vaccine (v-Oka) is highly attenuated in the skin, yet retains its neurovirulence and may reactivate and damage sensory neurons. Thus, the neuro-attenuated vaccine is in a great demand. In this issue, Silver and Zhu provide us a comprehensive review on the development of a genetically-defined live-attenuated VZV vaccine which could prevent neuronal and latent infection. The cover image shows the syncytia formation in VZV-infected ARPE-19 cells. Cells were infected with GPF-VZV, stained with WGA-Alexa Fluor 594 probe (red) for cell membrane, and DAPI (blue) for nuclei. (The microscopy image is provided by Dr. Hua Zhu, Rutgers-New Jersey Medical School, USA.)
Article List:
Review
Varicella zoster virus (VZV) is the causative agent of varicella (chicken pox) and herpes zoster (shingles). After primary infection, the virus remains latent in sensory ganglia, and reactivates upon weakening of the cellular immune system due to various conditions, erupting from sensory neurons ..., Abstract
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Research Article
Monkey B virus (Macacine herpesvirus 1; BV) is noted for its extreme neurovirulence in humans. Since the vhs protein encoded by the UL41 gene has been shown to be a neurovirulence factor in the related human herpes simplex viruses, the role of the UL41 gene in BV neurovirulence was investigated. BV ..., Abstract
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Research Article
In this study, we investigated the in vitro antiviral activity of the mycelia of higher mushrooms against influenza virus type A (serotype H1N1) and herpes simplex virus type 2 (HSV-2), strain BH. All 10 investigated mushroom species inhibited the reproduction of influenza virus strain A/FM/1/47 ..., Abstract
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Research Article
An amino acid mutation (R127→I) in the 3A non-structural protein of an FMDV serotype Asia1 rabbit-attenuated ZB strain was previously found after attenuation of the virus. To explore the effects of this mutation on viral replication and infection, the amino acid residue isoleucine (I) was changed ..., Abstract
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Research Article
The CD4 binding site (CD4bs) of envelope glycoprotein (Env) is an important conserved target for anti-human immunodeficiency virus type 1 (HIV-1) neutralizing antibodies. Neutralizing monoclonal antibodies IgG1 b12 (b12) could recognize conformational epitopes that overlap the CD4bs of Env. ..., Abstract
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