Issue of Virologica Sinica
Animal models of lung infection and severe pneumonia by severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome cornavirus (MERS-CoV) are still lacking. In this issue, acute pneumonia and severe lung injuries were successfully induced in C57BL/6 mice by the hepatic and neuronal tropic murine coronavirus A-59 (MHV-A59) via intranasal infection. Pathological changes of viral infection were closely monitored, and innate immune responses were studied. The cover image illustrates hemorrhages in the small blood vessels of the mouse lung infected with 1.5 x 105 PFU of MHV-A59 at day 5 post infection. See page 393–402 by Zhangsheng Yang et al. for details.
Article List:
Herpesviruses are a prominent cause of human viral disease, second only to the cold and influenza viruses. Most herpesvirus infections are mild or asymptomatic. However, when the virus invades the eye, a number of pathologies can develop and its associated sequelae have become a considerable source ..., Abstract
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Three crucial hurdles hinder studies on human cytomegalovirus (HCMV): strict species specifi city, differences between in vivo and in vitro infection, and the complexity of gene regulation. Ever since the sequencing of the whole genome was fi rst accomplished, functional studies on individual genes ..., Abstract
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Dengue virus (DENV) has four distinct serotypes. DENV infection can result in classic dengue fever and life-threatening dengue hemorrhagic fever/dengue shock syndrome. In recent decades, DENV infection has become an important public health concern in epidemic-prone areas. Vaccination is the most ..., Abstract
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Research Article
Middle East respiratory syndrome coronavirus (MERS-CoV) has emerged in the Arabian Gulf region, with its epicentre in Saudi Arabia, the host of the ‘Hajj’ which is the world's the largest mass gathering. Transmission of MERS-CoV at such an event could lead to its rapid worldwide dissemination. ..., Abstract
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Research Article
Full-length nucleoproteins from Ebola and Marburg viruses were expressed as His-tagged recombinant proteins in Escherichia coli and nucleoprotein-based enzyme-linked immunosorbent assays (ELISAs) were established for the detection of antibodies specifi c to Ebola and Marburg viruses. The ELISAs ..., Abstract
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Research Article
HIV-1 envelope glycoprotein is reported to interact with α4β7, an integrin mediating the homing of lymphocytes to gut-associated lymphoid tissue, but the signifi cance of α4β7 in HIV-1 infection remains controversial. Here, using HIV-1 strain BaL, the ..., Abstract
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Research Article
It remains challenging to develop animal models of lung infection and severe pneumonia by severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome cornavirus (MERS-CoV) without high level of containment. This inevitably hinders understanding of virushost ..., Abstract
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Research Article
Despite the long availability of a traditional prophylactic vaccine containing the HBV surface antigen (HBsAg) and aluminum adjuvant, nearly 10% of the population remains unable to generate an effective immune response. Previous studies have indicated that hepatitis B virus (HBV) PreS2-S is ..., Abstract
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