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Issue of Virologica Sinica
The outcome of hepatic B virus (HBV) infection is the result of complex
interactions between replicating HBV and the innate/adaptive immune system.
As an important lectin complement pathway activator, human ficolin-2 is
secreted from liver cells and contributes to the clearance of viral infections
and lysis of enveloped virions, which has been implicated as an anti-infection
innate immune molecule. In this issue, a research group lead by Drs. Xiao-
Lian Zhang and Fengling Luo, investigated the serum and liver tissue ficolin-2
levels, in a cohort of individuals with chronic HBV infections, hepatocellular
carcinoma (HCC) and liver cirrhosis. And their findings suggest that serum
and intrahepatic ficolin-2 levels may be considered as one of the indicators for
the response of chronic HBV infection, HCC and cirrhosis. The cover image
shows the decreased ficolin-2 expression in HCC cells compared to adjacent
normal hepatic cells from HCC patients. See page 249–260 for details.
Article List:
Review
Endogenous retroviruses (ERVs) are a component of the vertebrate genome and originate from
exogenous infections of retroviruses in the germline of the host. ERVs have coevolved with their
hosts over millions of years. Envelope glycoproteins of endogenous retroviruses are often expressed
in the ..., Abstract
Research Article
Human ficolin-2 is an important lectin complement pathway activator that is secreted from
liver cells and has been implicated as an anti-infection innate immune molecule. However, the
role of ficolin-2 protein and its dynamic changes over the course of and in the prognosis of
chronic hepatitis B ..., Abstract
Research Article
Hepatitis B virus (HBV) infection is one of the most serious and prevalent viral diseases in the
world. Although several anti-HBV drugs have been used clinically, their side and adverse effects
limit treatment efficacy. Therefore, it is necessary to identify novel potential anti-HBV agents. ..., Abstract
Research Article
Coxsackievirus A16 (CA16) is one of the major causes of hand, foot, and mouth disease (HFMD)
worldwide, which is a common illness that affects children. The frequent occurrence of HFMD
outbreaks has become a serious public health problem in Asia. Therefore, it is important to
understand the ..., Abstract
Research Article
Japanese encephalitis is a mosquito borne disease and is the leading cause of viral encephalitis in
the Asia-Pacific area. The causative agent, Japanese encephalitis virus (JEV) can be phylogenetically
classified into five genotypes based on nucleotide sequence. In recent years, genotype I (GI) ..., Abstract
Research Article
Phytoplankton viruses are important components of aquatic ecosystems. However, their prevalence
and genetic diversity in marine and freshwater systems are largely under estimated owing to
the immense size of water bodies and limitations in virus discovery techniques. In this study,
we conducted ..., Abstract
Letter
In the present study, we reported the full genome sequence
of a novel bacteriophage, designated as IME-
16, via screening pathogens from a throat swab obtained
from a patient with an unexplained fever. The viral
DNA and RNA were extracted using a High Pure Viral
RNA Kit (Roche, Germany). ..., Abstract
Letter
In this report, we presented the construction of an infectious
full-length clone and a recombined EV71 cDNA
clone, from which the RNA transcripts could result in
CPE in transfected cells. Furthermore, we also found that
the 5′UTR of EV71 could influence the replication of
EV71, potentially ..., Abstract
Letter
We identified a novel strain of influezna A H9N2 virus
infection in chicken in China. Genomic and phylogenetic
investigation revealed that the internal genes of
the novel H9N2 virus strain were closely related to the
emerging human H10N8 virus. These results suggest that
the chicken H9N2 virus ..., Abstract
Letter
The main aim of this study is to determine whether
the recent fox rabies outbreaks represent an occasional
fluctuation in the borders of rabies virus habitat or it isa step toward widespread dissemination of fox rabies in
Asia. According to data presented at the conference “Towards
the ..., Abstract
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