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Issue of Virologica Sinica
The outcome of hepatic B virus (HBV) infection is the result of complex interactions between replicating HBV and the innate/adaptive immune system. As an important lectin complement pathway activator, human ficolin-2 is secreted from liver cells and contributes to the clearance of viral infections and lysis of enveloped virions, which has been implicated as an anti-infection innate immune molecule. In this issue, a research group lead by Drs. Xiao- Lian Zhang and Fengling Luo, investigated the serum and liver tissue ficolin-2 levels, in a cohort of individuals with chronic HBV infections, hepatocellular carcinoma (HCC) and liver cirrhosis. And their findings suggest that serum and intrahepatic ficolin-2 levels may be considered as one of the indicators for the response of chronic HBV infection, HCC and cirrhosis. The cover image shows the decreased ficolin-2 expression in HCC cells compared to adjacent normal hepatic cells from HCC patients. See page 249–260 for details.
Article List:
Endogenous retroviruses (ERVs) are a component of the vertebrate genome and originate from exogenous infections of retroviruses in the germline of the host. ERVs have coevolved with their hosts over millions of years. Envelope glycoproteins of endogenous retroviruses are often expressed in the ..., Abstract
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Research Article
Human ficolin-2 is an important lectin complement pathway activator that is secreted from liver cells and has been implicated as an anti-infection innate immune molecule. However, the role of ficolin-2 protein and its dynamic changes over the course of and in the prognosis of chronic hepatitis B ..., Abstract
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Research Article
Hepatitis B virus (HBV) infection is one of the most serious and prevalent viral diseases in the world. Although several anti-HBV drugs have been used clinically, their side and adverse effects limit treatment efficacy. Therefore, it is necessary to identify novel potential anti-HBV agents. ..., Abstract
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Research Article
Coxsackievirus A16 (CA16) is one of the major causes of hand, foot, and mouth disease (HFMD) worldwide, which is a common illness that affects children. The frequent occurrence of HFMD outbreaks has become a serious public health problem in Asia. Therefore, it is important to understand the ..., Abstract
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Research Article
Japanese encephalitis is a mosquito borne disease and is the leading cause of viral encephalitis in the Asia-Pacific area. The causative agent, Japanese encephalitis virus (JEV) can be phylogenetically classified into five genotypes based on nucleotide sequence. In recent years, genotype I (GI) ..., Abstract
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Research Article
Phytoplankton viruses are important components of aquatic ecosystems. However, their prevalence and genetic diversity in marine and freshwater systems are largely under estimated owing to the immense size of water bodies and limitations in virus discovery techniques. In this study, we conducted ..., Abstract
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In the present study, we reported the full genome sequence of a novel bacteriophage, designated as IME- 16, via screening pathogens from a throat swab obtained from a patient with an unexplained fever. The viral DNA and RNA were extracted using a High Pure Viral RNA Kit (Roche, Germany). ..., Abstract
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In this report, we presented the construction of an infectious full-length clone and a recombined EV71 cDNA clone, from which the RNA transcripts could result in CPE in transfected cells. Furthermore, we also found that the 5′UTR of EV71 could influence the replication of EV71, potentially ..., Abstract
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We identified a novel strain of influezna A H9N2 virus infection in chicken in China. Genomic and phylogenetic investigation revealed that the internal genes of the novel H9N2 virus strain were closely related to the emerging human H10N8 virus. These results suggest that the chicken H9N2 virus ..., Abstract
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The main aim of this study is to determine whether the recent fox rabies outbreaks represent an occasional fluctuation in the borders of rabies virus habitat or it isa step toward widespread dissemination of fox rabies in Asia. According to data presented at the conference “Towards the ..., Abstract
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