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Issue of Virologica Sinica
Hepatitis B virus (HBV) infection remains a major global health problem because current therapies rarely eliminate the replicative template of HBV, which is the covalently closed circular DNA (cccDNA). As an accurate and efficient genome editing tool, clustered regularly interspaced palindromic repeat (CRISPR)-associated (Cas) 9 system represents a very promising potential therapeutic tool for eradication of HBV, including cccDNA. In this issue, Cheng Peng et al. reviewed recent advances in the application of CRISPR/Cas9 as an inhibitor of HBV, and discussed the obstacles and possibilities of the CRISPR/Cas9 system as a curative therapy for chronic hepatitis B infection. The cover image shows CRISPR/Cas9 based gene editing in the background of HBV liver infection. See page 317–325 for details.
Article List:
Review
Hepatitis B virus (HBV) infection remains a major global health problem because current therapies rarely eliminate HBV infections to achieve a complete cure. A different treatment paradigm to effectively clear HBV infection and eradicate latent viral reservoirs is urgently required. In ..., Abstract
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Review
Every year, millions of individuals throughout the world are seriously affected by dengue virus. The unavailability of a vaccine and of anti-viral drugs has made this mosquito-borne disease a serious health concern. Not only does dengue cause fatalities but it also has a profoundly ..., Abstract
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Research Article
Recreational waters contaminated with human fecal pollution are a public health concern, and ensuring the safety of recreational waters for public use is a priority of both the Environmental Protection Agency (EPA) and the Centers for Disease Control and Prevention (CDC). Current recreational ..., Abstract
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Research Article
Japanese encephalitis virus (JEV) is one of the most common pathogens of severe viral encephalitis, which is a severe threat to human health. Despite instability of the JEV genome in bacteria, many strategies have been developed to establish molecular clone systems of JEV, providing convenient ..., Abstract
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Research Article
VP7 of group A rotavirus (RVA) contains major neutralizing epitopes. Using the antigenic protein VP6 as the vector, chimeric proteins carrying foreign epitopes have been shown to possess good immunoreactivity and immunogenicity. In the present study, using modified VP6 as the vector, three ..., Abstract
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Research Article
Respiratory syncytial virus (RSV) is the key underlying cause of acute lower respiratory tract infection in infants; however, no licensed vaccine against RSV infection is currently available. This study was undertaken to assess the preventive effect of vaccine on RSV infection. In this ..., Abstract
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Research Article
In the baculovirus shuttle vector (bacmid) system, a helper plasmid and a donor plasmid are employed to insert heterologous genes into a cloned baculovirus genome via Tn7 transposition in Escherichia coli. The helper and donor plasmids are usually cotransfected with constructed bacmids into ..., Abstract
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Research Article
The widespread use of antibiotics has caused serious drug resistance. Bacteria that were once easily treatable are now extremely difficult to treat. Endolysin can be used as an alternative to antibiotics for the treatment of drug-resistant bacteria. To analyze the antibacterial activity of ..., Abstract
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Letter
In this study, our main purpose was to determine whether PKoV causes histopathological lesions after infection of piglets. PCR results confirmed that the piglets were indeed infected by PKoV. Additionally, we chose healthy experimental animals in this study, reared under standard conditions ..., Abstract
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