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Virologica Sinica, 31 (1) : 24-30, 2016
Review
Recent progress in the discovery of inhibitors targeting coronavirus proteases
School of Life Sciences, Tianjin University, Tianjin 300072, China
 Correspondence: yanght@tju.edu.cn; chengchen@tju.edu.cn
(5465.65KB)  
Abstract
Coronaviruses (CoVs) can cause highly prevalent diseases in humans and animals. The fatal outbreak of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) highlights the threat posed by this unique virus subfamily. However, no specific drugs have been approved to treat CoV-associated diseases to date. The CoV proteases, which play pivotal roles in viral gene expression and replication through a highly complex cascade involving the proteolytic processing of replicase polyproteins, are attractive targets for drug design. This review summarizes the recent advances in biological and structural studies, together with the development of inhibitors targeting CoV proteases, particularly main proteases (Mpros), which could help develop effective treatments to prevent CoV infection.
Received: 29 Dec 2015  Accepted: 22 Jan 2016  Published online: 19 Feb 2016
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