Recent large outbreaks of Zika virus (ZIKV) in Oceania’s islands and the Americas have linked the ZIKV infection with occurrence of microcephaly in newborns. The virus can be passed from a pregnant woman to her fetus. Even worse, ZIKV has now spread to nearly 30 areas worldwide and become a global health threat. In this issue, the virological, epidemiological and clinical essentials of ZIKV infection is reviewed; the evolution and spread pattern of ZIKV is analyzed; an infectious ZIKV strain from in imported case in mainland China is reported. The cover shows the immunofluorescence image of C6/36 mosquito cells infected with the isolated ZIKV strain at 24 hour post-infection. See page 176–179 for details.