Issue of Virologica Sinica
Recent large outbreaks of Zika virus (ZIKV) in Oceania’s islands and the Americas have linked the ZIKV infection with occurrence of microcephaly in newborns. The virus can be passed from a pregnant woman to her fetus. Even worse, ZIKV has now spread to nearly 30 areas worldwide and become a global health threat. In this issue, the virological, epidemiological and clinical essentials of ZIKV infection is reviewed; the evolution and spread pattern of ZIKV is analyzed; an infectious ZIKV strain from in imported case in mainland China is reported. The cover shows the immunofluorescence image of C6/36 mosquito cells infected with the isolated ZIKV strain at 24 hour post-infection. See page 176–179 for details.
Article List:
News & Views
Since early 2015, an unprecedented outbreak of Zika virus (ZIKV) infection that recognized in northeast Brazil has spread to Latin America (Schuler-Faccini, 2016)., Abstract
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An emerging mosquito-borne arbovirus named Zika virus (ZIKV), of the family Flaviviridae and genus Flavivirus, is becoming a global health threat. ZIKV infection was long neglected due to its sporadic nature and mild symptoms. However, recently, with its rapid spread from Asia to the Americas ..., Abstract
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An effective vaccine for human immunodeficiency virus (HIV) is urgently needed to prevent HIV infection and progression to acquired immune deficiency syndrome (AIDS). As glycosylation of viral proteins becomes better understood, carbohydrate-based antiviral vaccines against special viruses have ..., Abstract
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Research Article
Recent outbreaks of Zika virus (ZIKV) infections in Oceania's islands and the Americas were characterized by high numbers of cases and the spread of the virus to new areas. To better understand the origin of ZIKV, its epidemic history was reviewed. Although the available records and information ..., Abstract
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Research Article
Coxsackievirus A16 (CVA16) is one of major pathogens of hand, foot and mouth disease (HFMD) in children. Long non-coding RNAs (IncRNAs) have been implicated in various biological processes, but they have not been associated with CVA16 infection. In this study, we comprehensively characterized the ..., Abstract
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Research Article
Bovine foamy virus (BFV) is a complex retrovirus that infects cattle. Like all retroviruses, BFV encodes a transactivator Tas protein (BTas) that increases gene transcription from viral promoters. BFV encodes two promoters that can interact with BTas, a conserved promoter in the 5' long terminal ..., Abstract
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Research Article
African swine fever (ASF) is a lethal hemorrhagic disease that affects wild and domestic swine. The etiological agent of ASF is African swine fever virus (ASFV). Since the first case was described in Kenya in 1921, the disease has spread to many other countries. No commercial vaccines are available ..., Abstract
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Research Article
Synthetic biology is a newly developed field of research focused on designing and rebuilding novel biomolecular components, circuits, and networks. Synthetic biology can also help understand biological principles and engineer complex artificial metabolic systems. DNA manipulation on a large ..., Abstract
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Research Article
Rabies, a zoonotic disease, causes > 55,000 human deaths globally and results in at least 500 million dollars in losses every year. The currently available rabies vaccines are mainly inactivated and attenuated vaccines, which have been linked with clinical diseases in animals. Thus, a rabies ..., Abstract
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Here, we describe a cell culture-based procedure for isolating the infectious ZIKV (GenBank KU963796) from a human serum sample (ca. 50 μL) with an extremely low viral load (Ct value = 32)., Abstract
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Here, we introduce an additional method that we believe has merits with respect to reducing labor, decreasing wait times, improving objectivity, and decreasing long-term costs. This new method, called fluorescently labeled infected cell inoculum titration (FLICIT), utilizes high-throughput ..., Abstract
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Recombination contributes greatly to the diversity of human immunodeficiency virus type 1 (HIV-1). A large number of recombinant strains have been found in China, particularly in Yunnan, which is considered the HIV-1 epicenter of China. Surveillance of unique recombinant forms is helpful for ..., Abstract
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we successfully isolated 152 cyanophage psbA clones from two paddy waters of NE China. Although the majority of psbA sequences observed in this study had relative high similarity with those from Japanese paddy water, two and seven specific cyanophage psbA groups were constructed inJPWs and this ..., Abstract
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