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Issue of Virologica Sinica
Human cytomegalovirus (HCMV), a member of β human herpesvirus, can be life-threatening for immunocompromised individuals (such as patients with AIDS and organ transplant recipients) and neonates. It may cause cytomegalic inclusion disease and brain development disorders in newborns, and sensorineural hearing loss in infants who are asymptomatic at birth. HCMV can infect many types of cell, however, whether Multipotent mesenchymal stromal cells (MSCs) support HCMV replication and the infection status of HCMV in MSCs remain unclear. In this issue, Qiao et al. investigated the infection ability and status of HCMV in MSCs (isolated from Wharton’s jelly of the human umbilical cord), and found that the MSCs were fully permissive for HCMV infection. The cover shows the efficiency of HCMV genome replication in MSCs. See page 219-228 for details.
Article List:
Giant viruses from the Mimiviridae family (Mimivirus, Megavirus, etc.) replicate inside their Acanthamoeba host by the mean of a large intracytoplasmic virion factory within which DNA transcription and replication take place using the virus encoded machineries. Members of the Mimiviridae have been ..., Abstract
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The International Committee on Taxonomy of Viruses (ICTV) has the decree to set the rules for the classification and naming of viruses. The species is the lowest level considered in the taxonomic hierarchy. In general, virus species are named according to the structure “ ..., Abstract
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Research Article
The multifunctional trans-activator Tat is an essential regulatory protein for HIV-1 replication and is characterized by high sequence diversity. Numerous experimental studies have examined Tat in HIV-1 subtype B, but research on subtype C Tat is lacking, despite the high prevalence ..., Abstract
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Research Article
A transmission bottleneck occurs during each human immunodeficiency virus (HIV) transmission event, which allows only a few viruses to establish new infection. However, the genetic characteristics of the transmitted viruses that are preferentially selected have not been fully elucidated. Here ..., Abstract
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Research Article
Congenital human cytomegalovirus (HCMV) infection is a leading infectious cause of birth defects. Previous studies have reported birth defects with multiple organ maldevelopment in congenital HCMV-infected neonates. Multipotent mesenchymal stromal cells (MSCs) are a group of stem/progenitor ..., Abstract
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Research Article
Within Baculoviridae, little is known about the molecular mechanisms of replication in betabaculoviruses, despite extensive studies in alphabaculoviruses. In this study, the promoters of nine late genes of the betabaculovirus Plutella xylostella granulovirus (PlxyGV) were cloned into a transient ..., Abstract
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Research Article
Fibroblast growth factor (FGF) is found throughout multicellular organisms; however, fgf homologs (vfgf) have only been identified among viruses in lepidopteran baculoviruses. The function of vFGFs from Group I alphabaculoviruses, including Autographa californica multiple ..., Abstract
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Research Article
Foot-and-mouth disease virus (FMDV) is the causative agent of a highly contagious disease in livestock. The viral proteinase Lpro of FMDV is involved in pathogenicity, and mutation of the Lpro SAP domain reduces FMDV pathogenicity in pigs. To determine the gene expression ..., Abstract
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Astrovirus is an enteric virus associated with sporadic diarrhea or large outbreaks of gastroenteritis (Mendez et al., 2013). Until 2008, human astroviruses (HAstVs) were classified into eight serotypes—HAstV-1 to HAstV- 8—based on the reactivity of their capsid protein with type-specific ..., Abstract
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Since April 2010, an outbreak of a new disease has elicited symptoms of high fever, loss of appetite, and reduction in egg production in layer ducks in eastern China; this phenomenon has now spread throughout China (Cao et al., 2011; Su et al., 2011). The causative agent of the disease was ..., Abstract
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Infectious bursal disease virus (IBDV) causes infectious bursal disease, a highly contagious immunosuppressive disease that affects young chickens and causes economic losses in the poultry industry worldwide. IBDV replicates mainly in actively dividing B lymphocytes within the bursa of ..., Abstract
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In this study, multiplex PCR was used to amplify both the B2L gene partial coding region and a housekeeping gene. A substantial amount of research has been conducted on the B2L gene, and this presents opportunities for comparisons between different strains around the world. Field strains have ..., Abstract
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Akabane virus (AKAV), an orthobunyavirus, is transmitted primarily by biting midges and is widely distributed throughout the world except the Europe. AKAV was first isolated from mosquitoes in Japan (Oya et al., 1961). Although pregnant cows, ewes, and goats infected with AKAV exhibit no ..., Abstract
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