Human cytomegalovirus (HCMV), a member of β human herpesvirus, can be life-threatening for immunocompromised individuals (such as patients with AIDS and organ transplant recipients) and neonates. It may cause cytomegalic inclusion disease and brain development disorders in newborns, and sensorineural hearing loss in infants who are asymptomatic at birth. HCMV can infect many types of cell, however, whether Multipotent mesenchymal stromal cells (MSCs) support HCMV replication and the infection status of HCMV in MSCs remain unclear. In this issue, Qiao et al. investigated the infection ability and status of HCMV in MSCs (isolated from Wharton’s jelly of the human umbilical cord), and found that the MSCs were fully permissive for HCMV infection. The cover shows the efficiency of HCMV genome replication in MSCs. See page 219-228 for details.