Issue of Virologica Sinica
Among six human coronaviruses, severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle-East respiratory syndrome coronavirus (MERSCoV) are connected with severe respiratory-tract infection, which lead to high case-fatality rates of ~10 and ~35%, respectively. The papain-like protease, a domain located in the middle part of the largest non-structural protein Nsp3, has proteolytic, deubiquitinating, and deISGylating activities. The latter two functions are involved in the suppression of the antiviral innate immune response of the host cell. In this issue, Lei and Hilgenfeld present the X-ray crystal structure of a complex between MERS-CoV PLpro and human ubiquitin (Ub) that is devoid of any covalent linkage between the two proteins. The cover shows five regions of the PLpro bind to two areas of the Ub. See page 288-299 for details.
Article List:
Emerging infectious diseases are major threats to human health. Most severe viral disease outbreaks occur in developing regions where health conditions are poor. With increased international travel and business, the possibility of eventually transmitting infectious viruses between different ..., Abstract
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Research Article
The papain-like protease (PLpro) of Middle-East respiratory syndrome coronavirus (MERS-CoV) has proteolytic, deubiquitinating, and deISGylating activities. The latter two are involved in the suppression of the antiviral innate immune response of the host cell. To contribute to an ..., Abstract
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Research Article
A novel Clade H5N1 reassortant virus caused several outbreaks in wild birds in some regions of China from late 2014 to 2015. Based on the genetic and phylogenetic analyses, the viruses possess a stable gene constellation with a Clade HA, a H9N2-derived PB2 gene and the other ..., Abstract
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Research Article
The relationship between the Filaggrin gene (FLG) rs2065955 polymorphism and susceptibility to Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) and EBV-negative gastric carcinoma (EBVnGC) was investigated in Shandong Province, China. We detected theFLG rs2065955 ..., Abstract
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Research Article
Aquareovirus species vary with respect to pathogenicity, and the nonstructural protein NS80 of aquareoviruses has been implicated in the regulation of viral replication and assembly, which can form viral inclusion bodies (VIBs) and recruit viral proteins to its VIBs in infected cells. NS80 ..., Abstract
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Research Article
Citrus tristeza virus (CTV) is one of the most economically important citrus viruses and harms the citrus industry worldwide. To develop reliable and effective serological detection assays of CTV, the major capsid protein (CP) gene of CTV was expressed in Escherichia coli BL21 (DE3) using ..., Abstract
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Research Article
Hepatitis A virus is a pathogen associated with water pollution. Contaminated drinking water can cause hepatitis A outbreaks, lead to economic losses, and even threaten human lives. It is difficult to detect low levels of hepatitis A virus in water, so the virus must be concentrated in order to ..., Abstract
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Coxsackievirus A16 (CA16) is one of the major viral pathogens associated with hand, foot, and mouth disease. CA16 belongs to the Enterovirus genus of the Picornaviridae family and possesses a single-stranded positivesense RNA genome (Mao et al., 2014). Reverse genetics is an important ..., Abstract
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The dengue virus (DENV) is a single-stranded positivesense RNA virus that belongs to the family Flaviviridae (Gubler, 2002), and has four serotypes, DENV1-DENV4, which are transmitted via Aedes aegypti and Aedes albopictus (Rodriguez-Roche and Gould ..., Abstract
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Baculoviruses are insect-specific viruses with a circular double-stranded DNA genome ranging in size from 80–180 kb (Lu et al., 2012). Two distinct types of virions have been identified during the infectious cycle of baculoviruses, namely budded virions (BVs) and occlusion- derived virions ..., Abstract
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Bacteriophages are viruses that attack bacteria and kill them through the lytic replication cycle. Many studies have reported that phages are more specific to bacteria than antibiotics are; thus, phage therapy has many potential applications in human medicine, with the advantage of having few ..., Abstract
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Pathogenic Escherichia coli cause chicken colibacillosis, which is economically devastating to the poultry industry worldwide (Bagheri et al., 2014). Owing to increasing antibiotic resistance, phage therapy reagents have been developed to treat bacterial infections (Xu et al., 2015)., Abstract
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Zika virus (ZIKV) has captured the attention of the world because of its potential to infect neural cells and its teratogenic effects on foetuses and the new born. The virus seems to have various modes of transmission and has been the subject of many reviews in the literature (example, Musso and ..., Abstract
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