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《中国病毒学》Virologica Sinica Vol. 31, No 6, 2016
Viral pathogens frequently hijack the host actin polymerization machinery to facilitate their infection. Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) is one of the unique insect virus that inducing actin polymerization occurring in the nucleus, which requires relocation of cytoplasmic actin polymerization machinery, including actin-related protein 2/3 complex (Arp2/3), to the nucleus. Therefore, the alphabaculovirus-infection system could serve as a research model for investigating the nuclear import mechanism of Arp2/3. In this issue, Wang et al. investigated the spatial changes of Arp2/3 subunits induced by the viral replication-associated protein Ac34 in Sf9 cells. The cover shows the relocation of Arp2/3 subunits (P40, Arp2, P34, P21, and P20) in the presence of the viral late gene product Ac34. See page 472-479 for details.
本期论文:
Review
IKKε作为一种非经典的IκB激酶,在天然免疫中被广泛研究。最近的研究发现IKKε在干扰素信号通路中发挥重要作用。同时, 最新的研究发现IKKε在获得性免疫中也具有重要的功能。IKKε负调控CD8 T 细胞激活,暗示IKKε可能是一个潜在的免疫治疗的靶点,可以通过抑制IKKε来提高抗病毒和抗肿瘤T细胞免疫。我们概述了IKKε在干 ..., 详细信息
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Review
天然免疫系统通过模式识别受体cGAS识别细胞内双链DNA来启动1型干扰素通路和自噬通路,二者协同作用抑制病原体感染并激活机体的细胞免疫应答。疱疹病毒的基因组属于双链DNA,在感染中别cGAS识别。然而,为了成功的进行持续性感染,疱疹病毒已进化出多个病毒基因来调节宿主免疫信号通路的不同方面。本综述详细总结了卡波氏肉 ..., 详细信息
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Review
目前,虽然已有较高效的预防性疫苗和抗病毒治疗方法,但乙型肝炎病毒(hepatitis B virus, HBV)感染,特别是慢乙肝感染仍然是一个全球性的健康问题。虽然对病毒的感染方式和它的复制周期已经有相对比较明确的认识,但是当前对病毒感染诱发的宿主细胞代谢异常的机制以及参与调控病毒复制的宿主因子还有待进一步挖,因此,通 ..., 详细信息
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Research Article
The actin nucleator actin-related protein complex (Arp2/3) is composed of seven subunits: Arp2,Arp3, p40/ARPC1 (P40), p34/ARPC2 (P34), p21/ARPC3 (P21), p20/ARPC4 (P20), and p16/ARPC5(P16). Arp2/3 plays crucial roles in a variety of cellular activities through regulation of actin polymerization. ..., 详细信息
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Research Article
The envelope fusion protein F of baculoviruses is a class I viral fusion protein which play a significant role during virus entry into insect cells. F is initially synthesized as a precursor (F0) and then cleaved into a disulfide-linked F1 and F2 subunits during the ..., 详细信息
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Research Article
埃博拉病毒(EBOV)主要感染人和灵长目动物,可引起严重的出血热,致死率最高可达90%。糖蛋白(GP)是埃博拉病毒唯一的囊膜蛋白,在病毒的吸附和侵入过程中发挥着重要的作用,并且可以刺激机体产生保护性免疫反应。然而至今,埃博拉病毒GP蛋白仍旧无法在大肠杆菌内成功表达,这也阻碍了对病毒蛋白功能的进一步深入研究。本 ..., 详细信息
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Letter
蛋白-蛋白相互作用在生物过程中伴有非常重要的角色。拆分荧光素酶互补试验(SRLCA)是研究蛋白间相互作用的方法之一。该技术是将荧光蛋白在合适的位点切开形成不发荧光的2个片段,这2个片段借助融合于其上的目标蛋白的相互作用,彼此靠近,重新形成能具有活性的荧光蛋白。卡波齐肉瘤相关疱疹病毒(KSHV)编码的蛋白激酶(ORF36) ..., 详细信息
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Letter
On July 2, 2015, four pigs with severe respiratory distress and high fever (>40.0 ℃) at a farm in Jeonpook province in the Southern region of South Korea were euthanized, and their lung tissues were collected and homogenized in PBS. The homogenized samples were inoculated into the wells of 6-well ..., 详细信息
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Letter
Here, we report what we believe is the first case of EBV-associated HMB from Europe. Follow-up schedules and the necessity of reporting of EBV-associated HMB cases are being discussed., 详细信息
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Letter
反向遗传学是研究新城疫病毒(NDV)基因功能、致病机制和新型疫苗候选株的有力工具。基于T7 RNA聚合酶建立的标准新城疫病毒反向遗传操作系统是通过锤头核酶(HamRz)和丁型肝炎病毒核酶(HdvRz)的自催化活性实现病毒反义基因组5'-末端和3'-末端的精确转录。本研究利用具有增强的自剪切活性的优化HdvRz序列,建立起了一种快 ..., 详细信息
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Letter
植物病毒病是我国烟草安全生产的重大威胁。为深入研究烟草四种病毒的分布、分子变异,本研究开展了烟草病毒病普查,在2010和2011年采集409份样品。RT-PCR方法用于检测这些样品,结果表明271份样品至少被一种病毒感染:TMV在221个样品中检测到, CMV在132个样品, PVY在86个样品,TEV在62个样品. 从阳性样品中,18 TMV 分离物 ..., 详细信息
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