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Virologica Sinica, 32 (1) : 16, 2017
Review
Progress towards understanding the pathogenesis of dengue hemorrhagic fever
1. Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing 100084, China
2. School of Life Science, Tsinghua University, Beijing 100084, China
 Correspondence: gongcheng@mail.tsinghua.edu.cn
(540.31KB)  
Abstract
Dengue virus (DENV) is a mosquito-borne virus belonging to the Flaviviridae family. There are 4 serotypes of DENV that cause human disease through transmission by mosquito vectors. DENV infection results in a broad spectrum of clinical symptoms, ranging from mild fever to dengue hemorrhagic fever (DHF), the latter of which can progress to dengue shock syndrome (DSS) and death. Researchers have made unremitting efforts over the last half-century to understand DHF pathogenesis. DHF is probably caused by multiple factors, such as virus-specific antibodies, viral antigens and host immune responses. This review summarizes the current progress of studies on DHF pathogenesis, which may provide important information for achieving effective control of dengue in the future.
Received: 22 Aug 2016  Accepted: 22 Aug 2016  Published online: 14 Nov 2016
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