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Issue of Virologica Sinica
Bats have been recognized as an important natural reservoir for zoonotic viruses affecting both humans and livestock. They are likely to shed deadly emerging pathogens through feces and urine, materials that can be highly infectious to humans. In this issue, Waruhiu et al. performed the first country-wide surveillance of bat-borne viruses in Kenya spanning from 2012–2015 covering sites perceived to have medium to high level bat-human interaction. Nine virus families were screened, and 8 were detected with varying distributions. The study provides new and extended knowledge with regards to the virus diversity in Kenyan bat species, and hence raises the public health concern on the importance of continuous surveillance (See page 101-114 for details). The cover is a photo captured during the investigation in a bat cave in Kenya. (Image courtesy of Prof. Zhengli Shi).
Article List:
Research Article
This is the first country-wide surveillance of bat-borne viruses in Kenya spanning from 2012-2015 covering sites perceived to have medium to high level bat-human interaction.The objective of this surveillance study was to apply a non-invasive approach using fresh feces to detect viruses circulating ..., Abstract
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Research Article
Rasmussen's encephalitis (RE) is a rare and severe progressive epileptic syndrome with unknown etiology.Infection by viruses,including human cytomegalovirus (HCMV),has been speculated to be a potential trigger for RE.However,no viral antigens have been detected in the brains of patients with ..., Abstract
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Research Article
Natural killer (NK) cell is a key component of innate immunity and plays an important role in host defense against virus infection by directly destroying infected cells.Influenza is a respiratory disease transmitted in the early phase of virus infection.Evasion of host innate immunity including NK ..., Abstract
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Research Article
Recent studies have declared that members of the ssDNA virus family Microviridae play an important role in multiple environments,as they have been found taking a dominant position in the human gut.The aim of this study was to analyze the overall composition of the gut virome in coronary ..., Abstract
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Research Article
Noroviruses are the leading cause of acute gastroenteritis in humans.Real-time reverse transcription-polymerase chain reaction (real-time RT-PCR) is a promising molecular method for the detection of noroviruses.In this study,the performance of three TaqMan real-time RT-PCR assays was assessed,which ..., Abstract
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Research Article
No ascovirus isolated from China has been sequenced so far.Therefore,in this study,we aimed to sequence the genome of Heliothis virescens ascovirus 3h (HvAV-3h) using the 454 pyrosequencing technology.The genome was found to be 190,519-bp long with a G+C content of 45.5%.We also found that it ..., Abstract
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In Morocco, molecular and genetic characterization of IBV strain diversity have been very limited. A long-term retrospective study on Moroccan isolates is required to improve understanding of IBV evolution and IB epidemiology. The objective of this report is to perform a retrospective analysis ..., Abstract
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In this study, we report a novel mosquito-borne reassortant Orbivirus species, which we named Banna orbivirus (BAOV). The virus was isolated from a Culex tritaeniorhynchus pool collected in Xishuangbanna, Yunnan Province, China in 2007. Whole genome and phylogenetic analyses revealed that BAOV is a ..., Abstract
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In this study, we characterized a QD-labeled nonenveloped aquareovirus. Our results showed that QDGCRVs maintained their native particle properties and showed excellent infectivity in host cells. To the best of our knowledge, this is the first study reporting the realization of in situ real-time ..., Abstract
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In summary, we developed a novel mutagenesis phenotypic assay with the following characteristics: (1) acquisition of extensive site-specific mutations through a PCR step and FSR; (2) production of a lentivirus pool expressing different polymerase mutants via one-time lentivirus packaging; (3) ..., Abstract
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Cumulative evidence supports the role of early-life viral infections, especially respiratory syncytial virus (RSV) and human rhinovirus (HRV), as major antecedents of childhood asthma (Lemanske, 2002; Jackson et al.,2008). In this study, the xTAG respiratory viral panel FAST (RVP FAST) assay, a ..., Abstract
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