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Issue of Virologica Sinica
Human cytomegalovirus (HCMV) infection is a leading cause of birth defects, primarily affecting the central nervous system and causing its maldevelopment. Hes1, a downstream effector of Notch signaling pathway, plays an essential role on maintaining neural progenitor /stem cells (NPCs) cell fate and fetal brain development. In this issue, Xi-Juan Liu et al. reported the first observation of Hes1 oscillatory expression in human NPCs, and found HCMV infection disrupting the Hes1 rhythm and down-regulates its expression. The cover is adopted from a two-photon fluorescence image of Hes1 staining in NPCs (kindly provided by Xi-Juan Liu and Min-Hua Luo), and further processed with pseudo-color (in teal) at cytosol part. Like Hes1 rhythm, water lily also holds its own pattern of flowering rhythm. See page 188–198 for details.
Article List:
Epstein-Barr virus (EBV) is an oncogenic virus that ubiquitously establishes life-long persistence in humans.To ensure its survival and maintain its B cell transformation function,EBV has developed powerful strategies to evade host immune responses.Emerging evidence has shown that microRNAs ..., Abstract
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Research Article
Human cytomegalovirus (HCMV) infection is a leading cause of birth defects,primarily affecting the central nervous system and causing its maldevelopment.As the essential downstream effector of Notch signaling pathway,Hes1,and its dynamic expression,plays an essential role on maintaining neural ..., Abstract
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Research Article
The Zika virus (ZIKV) is an arbovirus that has spread rapidly worldwide within recent times.There is accumulating evidence that associates ZIKV infections with Guillain-Barré Syndrome (GBS) and microcephaly in humans.The ZIKV is genetically diverse and can be separated into Asian and African ..., Abstract
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Rabies virus (RABV) is a highly neurotropic virus that follows clathrin-mediated endocytosis and pH-dependent pathway for trafficking and invasion into endothelial cells.Early (Rab5,EEA1) and late (Rab7,LAMP1) endosomal proteins play critical roles in endosomal sorting,maturity and targeting ..., Abstract
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Human endogenous retrovirus W env (HERV-W env) plays a critical role in many neuropsychological diseases such as schizophrenia and multiple sclerosis (MS).These diseases are accompanied by immunological reactions in the central nervous system (CNS).Microglia are important immunocytes in brain ..., Abstract
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Bats carry a variety of viruses,and some of them cause public health problems.Macau,which is famous for its gambling industry,has a complex population structure.The globalization in such an international metropolis has enhanced the chance of disease transmission.Therefore,surveillance of zoonotic ..., Abstract
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Research Article
Seoul virus (SEOV),which is predominantly carried by Rattus norvegicus,is one of the major causes of hemorrhagic fever with renal syndrome (HFRS) in China.Hubei province,located in the central south of China,has experienced some of the most severe epidemics of HFRS.To investigate the ..., Abstract
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In summary, we propose a model for the role of retromer in HCV replication. Upon HCV infection, retromer may provide double-membrane autophagosomal membranes for HCV replication. Our studies suggested a novel link between retromer and autophagy in HCV replication, which may provide new therapeutic ..., Abstract
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In summary, our findings showed that for correct identification of NPEVs, cell lines other than RD cells must be used. In addition, neutralization tests did not show high sensitivity for identification of all NPEVs. Finally, establishment of direct molecular tests with high sensitivity and ..., Abstract
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Here, laboratory detection, virus isolation, whole genome sequencing and phylogenetic analysis were performed to characterize the first imported case of Rift Valley fever virus infection returning from Angola., Abstract
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In conclusion, our current data demonstrate that MHV68-immortalized SL-1 cells can be recognized and controlled by specific cytotoxic T cells through CD95/CD95L-mediated apoptosis. This is in agreement with that CD4 T cells control the growth of EBV-infected cells through CD95/CD95L-mediated ..., Abstract
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