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Virologica Sinica, 32 (4) : 338, 2017
Host protein atlastin-1 promotes human immunodeficiency virus (HIV-1) replication
Laboratory of Medical Molecular Virology, School of Medicine, Nankai University, Tianjin 300071, China
 Correspondence: kongxh@nankai.edu.cn
In conclusion,we first found that HIV infection upregulates the ATL1 mRNA.Up-regulation of ATL1 contributes to HIV-1 replication and down-regulation of ATL1 in host cells inhibited the viral replication.The further research found that ATL1 promoted the level of Env expression on the cell surface and then promoted the cell-to-cell fusion.Truncated mutation experiments revealed that the GTPase domain of ATL1 is the key domain of promoting Env-regulated cell-cell fusion.Finally, through the kinetic experiment,we found that ATL1 was able to promote long-term replication of HIV-1. We believe that the characterization of ATL1 contributes to a better understanding of HIV-host interactions and can identify potential novel antiviral targets.
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Received: 24 Jul 2017  Accepted: 24 Jul 2017  Published online: 24 Jul 2017
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