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Virologica Sinica, 32 (4) : 328, 2017
Cypovirus capsid protein VP5 has nucleoside triphosphatase activity
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
 Correspondence: zhouxi@whu.edu.cn
As a major protein of cypovirus capsid shell,VP5 performs as the clamp protein to stabilize the capsid shell structure (Yu et al.,2008).And as a part of viral RNA (vRNA) replication machinery,VP5 has been found to possess an ATP-independent RNA chaperoning activity (Yang et al.,2014).Here,we report that VP5 also has the nucleoside triphosphatase (NTPase) activity,which can hydrolyze all kinds of NTPs and dNTPs.Thus,our finding reveals that VP5 is a multifunctional protein that may be involved in diverse processes during cypoviral life cycle.
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Received: 26 May 2017  Accepted: 26 May 2017  Published online: 26 May 2017
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