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Virologica Sinica, 32 (4) : 1, 2017
Letter ( Advanced Online Publication)
Antiviral activity of quercetin-3-β-O-D-glucoside against Zika virus infection
1. Special Pathogens Program, Public Health Agency of Canada, Winnipeg R3E 3R2, Canada
2. Shenzhen Key Laboratory of Pathogen and Immunity, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Shenzhen 511700, China
3. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
4. Department of Medical Microbiology, University of Manitoba, Winnipeg R3E 0J9, Canada
5. Functional Endoproteolysis Laboratory, Clinical Research Institute of Montreal, Montreal H2W 1R7, Canada
6. Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa K1H 8L6, Canada
 Correspondence: xiangguo.qiu@phac-aspc.gc.ca
(1026.37KB)  (288.34KB)  
Abstract
Q3G is a natural derivative of quercetin and is already widely used in various foods and drinks.Our results clearly demonstrated that Q3G exerts antiviral activity against ZIKV in both tissue culture and knockout mice, and that post-exposure in vivo treatment with Q3G could have a beneficial effect.In the future,Q3G should be tested in human cell lines (such as Huh-7,HeLa,or K048, a fetal brain neural stem cell line) to provide further data supporting its potential efficacy in humans;in addition, live viral loads or viremia should be tested in treated animals to supplement the survival results observed in this study.Although the treatment regimens will need to be further optimized (i.e.,dosage,frequency of treatment, and administration routes),our results support the results of Q3G efficacy studies in nonhuman primates against ZIKV infection.Further studies will also be needed to investigate the mechanism of Q3G antiviral action,in order to obtain valuable insights into the design of novel targets for antiviral therapeutics in the future.
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Received: 5 Sep 2017  Accepted: 5 Sep 2017  Published online: 13 Sep 2017
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