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Virologica Sinica, 32 (5) : 4, 2017
Letter ( Advanced Online Publication)
Interplay between hepatitis C virus and ARF4
1. MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100176, China
2. Department of Emergency, 171 st Hospital of PLA, Jiujiang 332000, China
 Correspondence: keyouyang001@163.com;armzhang@hotmail.com
(420.18KB)  
Abstract
In summary, we show here that HCV infection is associated with an upregulation of ARF4, which promotes HCV replication. Upon HCV infection, CREB3 was redistributed to nucleus and activated ARF4 transcription.Our studies demonstrate a host factor ARF4 upregulated in HCV replication, which may provide new therapeutic targets for antiviral therapy.
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Received: 18 Aug 2017  Accepted: 13 Sep 2017  Published online: 13 Sep 2017
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