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Virologica Sinica, 32 (5) : 369, 2017
Review
Lipids, lipid metabolism and Kaposi’s sarcoma-associated herpesvirus pathogenesis
1. Department of Genetics, Louisiana State University Health Sciences Center, Louisiana Cancer Research Center, New Orleans 70112, USA
2. Department of Pediatrics, East Hospital, Tongji University School of Medicine, Shanghai 200120, China
3. Research Center for Translational Medicine and Key Laboratory of Arrhythmias, East Hospital, Tongji University School of Medicine, Shanghai 200120, China
4. Department of Pathology, Tulane University Health Sciences Center, Tulane Cancer Center, New Orleans 70112, USA
5. Department of Microbiology and Immunology, Division of Infectious Diseases, Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
 Correspondence: ldai@lsuhsc.edu;zqin@lsuhsc.edu
(1442.66KB)  
Abstract
Lipids are essential for mammalian cells to maintain many physiological functions. Emerging evidence has shown that cancer cells can develop specific alterations in lipid biosynthesis and metabolism to facilitate their survival and various malignant behaviors. To date, the precise role of cellular lipids and lipid metabolism in viral oncogenesis is still largely unclear with only a handful of literature covering this topic to implicate lipid metabolism in oncogenic virus associated pathogenesis. In this review, we focus on the role of lipid biosynthesis and metabolism in the pathogenesis of the Kaposi’s sarcoma-associated herpesvirus, a common causative factor for cancers arising in the immunocompromised settings.
Received: 2 Jun 2017  Accepted: 5 Sep 2017  Published online: 10 Oct 2017
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