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Virologica Sinica, 32 (5) : 1, 2017
Research Article (advanced Online Publication)
Hepatitis C virus-induced prion protein expression facilitates hepatitis C virus replication
1. State Key Laboratory of Virology
Center for Molecular Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
2. University of the Chinese Academy of Sciences, Beijing 100000, China
 Correspondence: cyli@wh.iov.cn
(659.88KB)  (107.86KB)  
Abstract
Hepatitis C virus (HCV) infects approximately 180 million people worldwide.Significant progress has been made since the establishment of in vitro HCV infection models in cells.However,the replication of HCV is complex and not completely understood.Here,we found that the expression of host prion protein (PrP) was induced in an HCV replication cell model.We then showed that increased PrP expression facilitated HCV genomic replication.Finally,we demonstrated that the KKRPK motif on the N-terminus of PrP bound nucleic acids and facilitated HCV genomic replication.Our results provided important insights into how viruses may harness cellular protein to achieve propagation.
Received: 22 Jun 2017  Accepted: 18 Sep 2017  Published online: 25 Oct 2017
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