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Virologica Sinica, 32 (5) : 1, 2017
Letter (advanced Online Publication)
Identification of a novel torque teno mini virus in cerebrospinal fluid from a child with encephalitis
1. Wuxi school of medicine, Jiangnan University, Wuxi 214122, China
2. Public Health Research Center, Jiangnan University, Wuxi 214122, China
3. Department of Liver Disease, Wuxi No. 5 People's Hospital affiliated to Jiangnan University, Wuxi 214073, China
4. Department of Radiology, Affiliated Hospital of Jiangnan University, Wuxi 214062, China
 Correspondence: gyan@stu.edu.cn;Lu_z_h@126.com
(489.32KB)  (135.55KB)  
Abstract
Anelloviruses are single-strand circular DNA viruses and ubiquitous within the human population. Although there is no direct evidence, many studies have suggested the anelloviruses may be associated with a variety of diseases. In this study, a novel torque teno mini virus (TTMV) was detected in a child with unexplained encephalitis. The detected virus had a circular genome of 2943 nt in length and 3 open reading frames. It shared 45.4% – 35.9% nucleotide identities with known TTMV species and < 35% with the other species of anellovirus, which suggested it might belong to a new species within the genus Betatorquevirus. Phylogenetic analysis based on the amino acid sequences of ORF1 showed that this virus represented a distinct branch within the diversity of anellovirus. Whether this novel anellovirus strain is associated with encephalitis requires further study.
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Received: 17 Oct 2017  Accepted: 17 Oct 2017  Published online: 17 Oct 2017
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