Hello guest, Register  |  Sign In
Virologica Sinica, 32 (5) : 396, 2017
Research Article
Prevalence of Kaposi’s sarcoma-associated herpesvirus in Uygur and Han populations from the Urumqi and Kashgar regions of Xinjiang, China
1. Key Laboratory of Xinjiang Endemic and Ethnic Disease & Department of Biochemistry, School of Medicine, Shihezi University, Shihezi 832000, China
2. Department of Stomatology, The First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi 832000, China
3. Division of AIDS Research, National Traditional Chinese Medicine Clinical Research Bases in Xinjiang, Urumqi 830000, China
4. Department of Gynecology, Xinjiang Uygur Autonomous Region People's Hospital, Urumqi 830001, China
5. Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China
6. Nebraska Center of Virology and the School of Biological Sciences, University of Nebraska-Lincoln, Lincoln 68583, USA
 Correspondence: tjzhang@shmu.edu.cn; yzeng910@163.com
(618.22KB)  (452.23KB)  
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the infectious etiologic agent associated with Kaposi’s sarcoma (KS), primary effusion lymphoma, and multicentric Castleman disease. It has been shown that high KSHV prevalence and high incidence of both classic KS and AIDSassociated KS are found mostly among people of Uygur ethnicity in Xinjiang, while people of Han ethnicity in Xinjiang have a higher KSHV seroprevalence than those of other Han populations in mainland China. However, it is still unclear why there is such geographical and population variation in KSHV distribution in China. In this work, we focused on the populations in the Kashgar region and Urumqi area, where a total of 1294 research subjects were randomly selected to investigate the potential correlation between KSHV prevalence and different ethnicities in endemic areas of Xinjiang, and to determine risk factors that may affect KSHV infection rates or KS incidence. We identified a high seroprevalence of KSHV and high peripheral blood DNA infection in the general Uygur and Han populations in both Urumqi and Kashgar regions of Xinjiang, and determined that advancing age, low education level, and stationary population status affect KSHV infection rates. Further, KSHV-positive Uygur participants were shown to have higher prevalence of neutralizing antibodies and neutralizing antibody titers than KSHV-positive Han participants.
Received: 29 Jul 2017  Accepted: 18 Sep 2017  Published online: 25 Oct 2017
Home |  Resources |  About Us |  Support |  Contact Us |  Privacy |  Powered by CanSpeed | 
Copyright © 2015 Virologica Sinica. All rights reserved