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Virologica Sinica, 32 (5) : 357, 2017
Review
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers
1. MOH & MOE Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences Shanghai Medical College of Fudan University, Shanghai 200032, China
2. Amity Institute of Virology and Immunology, Block-J3, Sector-125, Amity University, Uttar Pradesh 201303, India
3. Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology Shanghai Jiao Tong University, Shanghai 200240, China
 Correspondence: sbanerjee@amity.edu;fangwei@sjtu.edu.cn;qiliang@fudan.edu.cn
(2013.02KB)  
Abstract
Activation of specific sets of protein kinases by intracellular signal molecules has become more and more apparent in the past decade. Phosphorylation, one of key posttranslational modification events, is activated by kinase or regulatory protein and is vital for controlling many physiological functions of eukaryotic cells such as cell proliferation, differentiation, malignant transformation, and signal transduction mediated by external stimuli. Moreovers, the reversible modification of phosphorylation and dephosphorylation can result in different features of the target substrate molecules including DNA binding, protein-protein interaction, subcellular location and enzymatic activity, and is often hijacked by viral infection. Epstein-Barr virus (EBV) and Kaposi’s sarcomaassociated herpesvirus (KSHV), two human oncogenic gamma-herpesviruses, are shown to tightly associate with many malignancies. In this review, we summarize the recent progresses on understanding of molecular properties and regulatory modes of cellular and viral proteins phosphorylation influenced by these two tumor viruses, and highlight the potential therapeutic targets and strategies against their related cancers.
Received: 11 Sep 2017  Accepted: 23 Oct 2017  Published online: 30 Oct 2017
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