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Virologica Sinica, 33 (1) : 104, 2018
Serological Evidence of Bat SARS-Related Coronavirus Infection in Humans, China
1 CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
2 University of Chinese Academy of Sciences, Beijing 100049, China
3 School of Health Sciences, Wuhan University, Wuhan 430071, China
4 EcoHealth Alliance, New York, NY 10001, USA
5 Yunnan Provincial Key Laboratory for Zoonosis Control and Prevention, Yunnan Institute of Endemic Diseases Control and Prevention, Dali 671000, China
6 School of Public Health, Dali University, Dali 671000, China
7 Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore
 Correspondence: zlshi@wh.iov.cn
(788.89KB)  (338.78KB)  
In our previous works, we have reported genetically diverse SARS-related coronaviruses (SARSr-CoV) in a single bat cave, Yunnan province, China, and suggested that some SARSr-CoVs may have high potential to infect humans without the necessity for an intermediate host. In this report, we developed a specific ELISA based on the nucleocapsid protein of a SARSr-CoV strain and detected its antibody in humans who are highly exposed to bat populations. From 218 human serum samples, 6 were positive against the nucleocapsid protein by ELISA and further confirmed by Western blot. For the first time, we demonstrated the SARSr-CoV had spillover to humans, although did not cause clinical diseases.
Received: 21 Nov 2017  Accepted: 8 Jan 2018  Published online: 27 Mar 2018
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