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Virologica Sinica, 33 (2) : 209, 2018
Characteristics of HIV-1 Molecular Epidemiology in Suzhou, China, from 2009 to 2014
1 Department of Clinical Laboratory, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou 215031, China
2 The Institutes of Biological and Medical Sciences, Soochow University, Suzhou 215123, China
3 Basic Medical College of Jiamusi University, Jiamusi University, Jiamusi 154007, China
4 Suzhou Center for Disease Control and Prevention, Suzhou 215004, China
 Correspondence: yaxuerong@sohu.com;syh430071@163.com
(734.34KB)  (434.89KB)  
Suzhou is experiencing a dynamic human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) epidemic. While serology based surveillance systems have reported the spread of HIV/AIDS, detailed tracking of its molecular epidemiology and transmission in populations remains mostly undetermined. Here, we conducted a molecular epidemiology study involving 261 HIV-1-positive serum samples collected in Suzhou from 2009 to 2014 and systematically analyzed the dynamic characteristics of virus genetic variation. Sequencing data showed that the predominant HIV-1 subtype was CRF01_AE (52.1%), followed by CRF07_BC (30.3%), CRF08_BC (8.4%), and B (8.0%). The genotype distance of the B-subtype strain was great and its degree of variation was high. Interestingly, a cluster of eight members was found in the phylogenetic tree of CRF01_AE samples from men who have sex with men (MSM). Although the main transmission route of HIV-1 circulating in Suzhou appeared to be sexual transmission, maternal vertical transmission was also observed in this study. These data provide the basis for a rational and effective prevention and control strategy to prevent further spread of HIV-1 in Suzhou.
Received: 11 Oct 2017  Accepted: 12 Jan 2018  Published online: 16 Mar 2018
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