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Virologica Sinica, 33 (3) : 241, 2018
Research Article
Exhaustive Exercise Does Not Affect Humoral Immunity and Protection after Rabies Vaccination in a Mouse Model
1. Department of Physical Education, Huazhong Agricultural University, Wuhan 430070, China
2. School of Foreign Languages, Huazhong Agricultural University, Wuhan 430070, China
3. State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China
4. College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China
 Correspondence: mikchail@163.com;tiandayong2008@163.com
(1386.54KB)  
Abstract
Rabies is one of the most dangerous and widespread zoonosis and is characterized by severe neurological signs and a high case-mortality rate of nearly 100%. Vaccination is the most effective way to prevent rabies in humans and animals. In this study, the relationship between exhaustive exercise and the humoral immune response after immunization with inactivated rabies vaccine was investigated in a mouse model with one-time exhaustive exercise. It was found that compared with the mice with no exercise after vaccination, no significant differences were found in those with exhaustive exercise after vaccination on body-weight changes, virus-neutralizing antibody (VNA) titers, antibody subtypes and survivor ratio after lethal rabies virus (RABV) challenge. This study indicated that exhaustive exercise does not reduce the effects of the rabies inactivated vaccine.
Received: 17 Dec 2017  Accepted: 31 Jan 2018  Published online: 28 Mar 2018
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