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Virologica Sinica, 33 (4) : 314, 2018
Research Article
Stress Granule Formation is One of the Early Antiviral Mechanisms for Host Cells Against Coxsackievirus B Infection
1. Department of Microbiology, Harbin Medical University, Harbin 150081, China
2. Department of Cell Biology, Harbin Medical University, Harbin 150081, China
 Correspondence: zhaowr@hrbmu.edu.cn;zhonghum@hrbmu.edu.cn
(2327.73KB)  
Abstract
Stress granules (SGs) are intracellular granules formed when cellular translation is blocked and have been reported to be involved in a variety of viral infections. Our previous studies revealed that SGs are involved in the coxsackievirus B (CVB) infection process, but the role of SGs in CVB infection has not been fully explored. In this study, we found that CVB type 3 (CVB3) induced SG formation in the early phase of infection. Results showed that levels of CVB3 RNA and protein were significantly inhibited during the early stage of CVB3 infection by the promoted formation of SGs, while viral RNA and protein synthesis were significantly promoted when SG formation was blocked by knocking down the SG proteins, G3BP1 and TIA1, separately or in combination. Our findings suggest that SG formation is one of the early antiviral mechanisms for host cells against CVB infection.
Received: 19 May 2018  Accepted: 8 Sep 2018  Published online: 13 Jun 2018
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