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Virologica Sinica, 33 (4) : 369, 2018
Letter
KIR2DL2/C1 is a Risk Factor for Chronic Infection and Associated with Non-response to PEG-IFN and RBV Combination Therapy in Hepatitis C Virus Genotype 1b Patients in China
1. Medical College, Jianghan University, Wuhan 430056, China
2. Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
3. Department of Pathogen Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
 Correspondence: binlian17@jhun.edu.cn
(441.00KB)  (437.07KB)  
Abstract
Natural killer (NK) cells play an important role in innate immunity to hepatitis C virus (HCV), especially in response to HCV infections. Killer cell immunoglobulin-like receptors (KIRs) are the primary receptors of NK cells that regulate NK cell behavior to antivirus infection response. Our aim was to determine the association of KIR frequencies with HCV infection and therapy responses in a Chinese Han population, and we compared that of 333 patients infected with HCV-1b and 320 healthy controls, as well as 36 non-responders (NR) and 62 sustained virological responders (SVR) treated with a combination therapy of pegylated alpha interferon and ribavirin. It was found that the frequency of the KIR2DL2 gene was higher in patients infected with HCV than that in controls. Additionally, a higher frequency of the KIR2DL2 gene was observed in NRs compared with SVRs, which was also supported by the results of a meta-analysis. Moreover, in a Chinese Han population, we found that KIR2DL2 in combination with its ligand HLA-C1 is a risk factor for infection and is not useful for HCV therapy; also, the KIR2DL2 gene alone is a risk factor for the development of infection. Results suggested that KIR2DL2 downregulates the killing ability of NK cells in the clearance of HCV.
Received: 27 Jan 2018  Accepted: 8 Sep 2018  Published online: 23 Jul 2018
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