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Virologica Sinica, 33 (4) : 335, 2018
Research Article
Tandem 3'UTR Patterns and Gene Expression Profiles of Marc-145 Cells During PRRSV Infection
1. State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510006, China
2. School of Biology and Food Engineering, Changshu Institute of Technology, Changshu 215500, China
 Correspondence: caoych@mail.sysu.edu.cn
Porcine reproductive and respiratory syndrome virus (PRRSV) causes substantial economic losses to the global pig industry. Alternative polyadenylation (APA) is a mechanism that diversifies gene expression, which is important for tumorigenesis, development, and cell differentiation. However, it is unclear whether APA plays a role in the course of PRRSV infection. To address this issue, in this study we carried out a whole-genome transcriptome analysis of PRRSVinfected Marc-145 African green monkey kidney cells and identified 185 APA switching genes and 393 differentially expressed genes (DEGs). Most of these genes were involved in cellular process, metabolism, and biological regulation, and there was some overlap between the two gene sets. DEGs were found to be more directly involved in the antiviral response than APA genes. These findings provide insight into the dynamics of host gene regulation during PRRSV infection and a basis for elucidating the pathogenesis of PRRSV.
Received: 11 May 2018  Accepted: 8 Sep 2018  Published online: 1 Aug 2018
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