Serological Cross Reactivity between Zika and Dengue Viruses in Experimentally Infected Monkeys

Shailendra Mani; Chee Wah Tan; Lin-Fa Wang; Danielle E. Anderson

doi:10.1007/s12250-018-0048-8

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Virologica Sinica, 33 (4) : 378, 2018

Letter

Serological Cross Reactivity between Zika and Dengue Viruses in Experimentally Infected Monkeys

Shailendra Mani#, Chee Wah Tan#, Lin-Fa Wang Correspondence author

, Danielle E. Anderson Correspondence author

Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore

Correspondence: linfa.wang@duke-nus.edu.sg;danielle.anderson@duke-nus.edu.sg

ORCID: 0000-0003-2752-0535;0000-0003-4791-5024

DOI: 10.1007/s12250-018-0048-8

(439.42KB)

(314.27KB)

摘要

In the absence of serum panels from individuals with absolute defined infection status, sera from experimentally infected monkeys were generated to cover all four infection scenarios with Zika or dengue virus alone as well as Zika infection followed by dengue and dengue infection followed by Zika. Our data indicated that no currently available single assay platform is sufficiently specific to serologically determine Zika positivity in the presence of prior exposure to dengue and vice versa.

关键词: Zika virus (ZIKV); Dengue virus (DENV); antibody; cross reactivity; serology; monkey infection

Received: 11 Jun 2018 Accepted: 8 Sep 2018 Published online: 28 Aug 2018