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《中国病毒学》Virologica Sinica Vol. 33, No 4, 2018
Stress granules (SGs) are intracellular granules formed when cellular translation is blocked. Viral infections can induce the formation of SGs, which in turn promote or inhibit viral infection. In this issue, Xia Zhai et al. investigated the effect of coxsackievirus B type 3 (CVB3) infection on SG formation, and found that CVB3 could induce SG formation in the early phase of infection, while SGs could in turn restrict the biosynthesis of CVB3 in host cells. The cover image shows the formation of stress granules (green dots) in HeLa cells infected with CVB3 (red) for 6 h (kindly provided by Prof. Zhaohua Zhong). See page 314–322 for details.
本期论文:
Research Article
Hepatitis C (HCV) is a global health concern, notably in Southeast Asia, and in Laos the presentation of the disease is poorly known. Our objective was thus to describe a comprehensive HCV infection pattern in order to guide national health policies. A study on a group of 1,765 patients formerly ..., 详细信息
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Research Article
Enteric viruses are the most common cause of acute gastroenteritis (AGE) in young children and a significant public health problem globally. Hospital admissions of children under 5 years of age with diarrhea are primarily associated with group A rotavirus (RVA) infection. In this retrospective ..., 详细信息
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Research Article
应激颗粒(Stress granule, SG)是细胞的蛋白质合成受阻时形成的、由RNA及RNA结合蛋白构成的细胞质聚集体。SG的形成与多种疾病包括病毒感染相关。我们之前的研究发现B组柯萨奇病毒(Coxsackievirus B,CVB)感染时有SG的形成,但SG的形成对CVB感染的影响则不清楚。本研究发现,SG的形成发生在CVB感染的早期;在这一阶段,促 ..., 详细信息
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Research Article
本研究旨在调查塞拉利昂埃博拉疫情后期埃博拉病毒感染的血清学特征。从2015年3月至12月,对共694例疑似埃博拉病毒病病例的877例血液样本进行分析,利用实时荧光RT-PCR检测病毒RNA,利用酶联免疫吸附试验(ELISA)和Luminex检测埃博拉病毒特异性抗体。在2015年3月至12月期间,埃博拉病毒载量和特异性IgM/IgG滴度呈整体下降趋势 ..., 详细信息
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Research Article
Porcine reproductive and respiratory syndrome virus (PRRSV) causes substantial economic losses to the global pig industry. Alternative polyadenylation (APA) is a mechanism that diversifies gene expression, which is important for tumorigenesis, development, and cell differentiation. However, it is ..., 详细信息
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Research Article
杆状病毒是一类对害虫生防效果良好的微生物。杆状病毒不仅在感染昆虫过程中影响到宿主的免疫,同时也会改变昆虫的行为。一些研究从病毒的角度去探讨病毒感染引起宿主昆虫行为变化的机理,但针对这种行为变化,尚无从宿主昆虫角度去探究基因表达变化与之相关性的研究。舞毒蛾核型多角体病毒诱导被感染的幼虫在染病后3天 到6 ..., 详细信息
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Research Article
波纹杂毛虫核型多角体病毒(CyunNPV)是一种分离自森林害虫波纹杂毛虫(鳞翅目枯叶蛾科)的潜在生物杀虫剂。在此篇研究中,我们分析了CyunNPV的基因组,并比较了它和其他Alpha属组I杆状病毒的基因组差异。454高通量测序结果显示:CyunNPV基因组全长为142,900bp,其中G+C含量为45%。生物信息学分析显示,其包含147个潜在的 ..., 详细信息
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Letter
自然杀伤细胞(NK cell)在丙肝病毒(HCV)感染中发挥着重要作用。杀伤性免疫球蛋白样受体(KIRs)是NK细胞表面的重要受体,它们可调控NK细胞的抗病毒功能。为了观察在中国汉族人群中KIR基因的出现频率与HCV感染以及治疗效果的差异,我们对333例HCV-1b感染者和320名健康人,以及在聚乙二醇α干扰素和利巴韦林联合治疗后追踪到的36 ..., 详细信息
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Letter
本研究针对我国南部、中部和北部地区猪场采集的730份病猪临床样本, 用PCR方法检测猪圆环病毒3型(PCV3)DNA,结果表明PCV3阳性率为14.25%。成功获得的6个病毒基因组可被划分为3个不同分支。不同PCV3阳性样品的检出率依次为肺脏、淋巴结、死胎、肾脏、脑、扁桃、脾脏、心脏和肝脏。PCV2和PRRSV是PCV3混合感染的主要病原。上 ..., 详细信息
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Letter
In the absence of serum panels from individuals with absolute defined infection status, sera from experimentally infected monkeys were generated to cover all four infection scenarios with Zika or dengue virus alone as well as Zika infection followed by dengue and dengue infection followed by Zika. ..., 详细信息
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