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Virologica Sinica, 33 (5) : 385, 2018
Review
Phylogeography, Transmission, and Viral Proteins of Nipah Virus
1 Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
2 University of Chinese Academy of Sciences, Beijing 100049, China
 Correspondence: liud@wh.iov.cn
(2841.22KB)  
Abstract
Nipah virus (NiV), a zoonotic paramyxovirus belonging to the genus Henipavirus, is classified as a Biosafety Level-4 pathogen based on its high pathogenicity in humans and the lack of available vaccines or therapeutics. Since its initial emergence in 1998 in Malaysia, this virus has become a great threat to domestic animals and humans. Sporadic outbreaks and person-to-person transmission over the past two decades have resulted in hundreds of human fatalities. Epidemiological surveys have shown that NiV is distributed in Asia, Africa, and the South Pacific Ocean, and is transmitted by its natural reservoir, Pteropid bats. Numerous efforts have been made to analyze viral protein function and structure to develop feasible strategies for drug design. Increasing surveillance and preventative measures for the viral infectious disease are urgently needed.
Received: 14 Jun 2018  Accepted: 5 Sep 2018  Published online: 11 Oct 2018
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