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Virologica Sinica, 33 (5) : 449, 2018
Characterization of Avian-like Influenza A (H4N6) Virus Isolated from Caspian Seal in 2012
1 Novosibirsk State University, Novosibirsk, Russia 630090
2 Federal State Budget Scientific Institution "Federal Research Center of Fundamental and Translational Medicine", Novosibirsk, Russia 630117
3 School of Biomedicine, Far Eastern Federal University, Vladivostok, Russia 690090
4 Federal Scientific Center of East Asia Terrestrial Biodiversity, Far Eastern Branch of Russian Academy of Sciences, Vladivostok, Russia 690022
5 CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, China
6 Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Taishan Medical College, Taian 271000, China
 Correspondence: mgulyaeva@gmail.com
Marine mammals are widely distributed and can be found almost in all coastal waters and coastlines around the world. The interface areas between marine and terrestrial environments provide natural habitats for aquatic and semiaquatic mammals as well as for reservoir species of avian influenza viruses (AIV) (Runstadler et al. 2013). Previous studies showed that wild aquatic birds, the natural reservoir of AIV, are able to transmit the virus to various mammals, including seals, swine, horses, muskrats, and humans (Webster et al. 1992; Reperant et al. 2009; Gulyaeva et al. 2017). Close contacts between sea mammals and wild birds on breeding-grounds could promote both interspecies transmission of AIV and virus establishment in a new host (Fereidouni et al. 2014). Various AIV subtypes (A/seal/ Massachusetts/80(H7N7), A/Seal/MA/133/82(H4N5), A/Seal/MA/3807/91(H4N6), A/Seal/MA/3911/92(H3N3), A/harbour seal/Mass/1/2011(H3N8) and A/harbor seal/NL/ PV14-221_ThS/2015(H10N7) etc.) have been isolated from different species of marine mammals during the last 30 years. AIV isolated from marine mammals and wild birds are closely related, which suggests that wild birds are the major source of AIV infection (Fereidouni et al. 2014; Bodewes et al. 2015). In addition, AIV can cross species barrier and replicate well in experimental mammals without prior adaptation (Driskell et al. 2012).
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Received: 24 Jul 2018  Accepted: 3 Sep 2018  Published online: 17 Oct 2018
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