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Virologica Sinica, 33 (5) : 459, 2018
Perspective
Targeting cIAPs, a New Option for Functional Cure of Chronic Hepatitis B Infection?
State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
 Correspondence: xiaoyzhang@smu.edu.cn
(450.35KB)  
Abstract
Hepatitis B virus (HBV) infection remains a great public health problem worldwide. Here, we discuss the rationality and possibility of cellular inhibitor of apoptosis proteins (cIAPs) as a therapeutic target for HBV functional cure, and introduce the ongoing Phase I clinical study of cIAPs antagonists APG-1387 for chronic hepatitis B treatment.
Received: 9 Aug 2018  Accepted: 30 Sep 2018  Published online: 29 Oct 2018
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