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Issue of Virologica Sinica
Host cell cytoskeletons have been reported to have close contact with viruses during virus entry, intracellular transport, replication, and egress process. In this issue, Yue Zhang et al. provide a brief overview of the function of the most prominent flaviviruses-induced or -hijacked cytoskeletal structures including actin, microtubules and intermediate filaments, mainly focus on infection by dengue virus, Zika virus and West Nile virus. The cover image shows host actin cytoskeleton (green) with decorated myosin molecular motor (red) in human osteosarcoma cells (kindly provided by Prof. Yaming Jiu). See page 30–41 for details.
Article List:
Since first isolation in 1947 from the Zika forest in Uganda, Zika virus (ZIKV) has been principally known as a benign agent associated with sporadic human infections in a restricted number of African countries. However, during 2015–2016, an Asian lineage of ZIKV caused an unprecedentedly large ..., Abstract
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Enterovirus 71 (EV71) is one of the main pathogens that causes hand-foot-and-mouth disease (HFMD). HFMD caused by EV71 infection is mostly self-limited; however, some infections can cause severe neurological diseases, such as aseptic meningitis, brain stem encephalitis, and even death. There are ..., Abstract
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RNA modifications are abundant in eukaryotes, bacteria, and archaea. N6-methyladenosine (m6A), a type of RNA modification mainly found in messenger RNA (mRNA), has significant effects on the metabolism and function of mRNAs. This modification is governed by three types of ..., Abstract
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The family of flaviviruses is one of the most medically important groups of emerging arthropod-borne viruses. Host cell cytoskeletons have been reported to have close contact with flaviviruses during virus entry, intracellular transport, replication, and egress process, although many detailed ..., Abstract
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Research Article
Hepatitis B virus (HBV) is an important human pathogen belonging to the Hepadnaviridae family, Orthohepadnavirus genus. Over 240 million people are infected with HBV worldwide. The reverse transcription during its genome replication leads to low fidelity DNA synthesis, which is the ..., Abstract
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Research Article
Echovirus 18 (E18), a serotype of Enterovirus B (EV-B) species, is an important pathogen in aseptic meningitis. E18 has rarely been detected in mainland China, but became the predominant pathogen associated with viral encephalitis (VE) and meningitis in Hebei province for the first time in 2015. To ..., Abstract
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Research Article
Exosomes are cell-derived vesicles that are secreted by many eukaryotic cells. It has recently attracted attention as vehicles of intercellular communication. Virus-infected cells release exosomes, which contain viral proteins, RNA, and pathogenic molecules. However, the role of exosomes in virus ..., Abstract
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Research Article
Enterovirus 71 (EV71), a major causative agent of hand, foot, and mouth disease, has caused periodic infection outbreaks in children in the Asia-Pacific region. In order to describe the largely unknown life cycle of EV71, the molecular basis of its virus-host interactions must first be determined. ..., Abstract
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Research Article
Oxymatrine (OMT), as the main active component of Sophoraflavescens, exhibits a variety of pharmacological properties, including anti-oxidative, anti-inflammatory, anti-tumor, and anti-viral activities, and currently is extensively employed to treat viral hepatitis; however, its effects on ..., Abstract
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Research Article
Dengue fever, caused by dengue viruses (DENVs), is a widespread mosquito-borne zoonotic disease; however, there is no available anti-dengue vaccine for worldwide use. In the current study, a DNA vaccine candidate (pV-D4ME) expressing prM-E protein of DENV serotype 4 (DENV-4) was constructed, and ..., Abstract
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The avian influenza virus (AIV) H5N7 was first isolated from wild birds in North America in 2001 (Spackman et al., 2007), and information on only 25 strains of this virus has been deposited in the Global Initiative on Sharing All Influenza Data ..., Abstract
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Infectious bursal disease (IBD), caused by IBD virus (IBDV), is one of the most devastating diseases of the poultry. Despite the use of mass- and intense-vaccination regimens, the disease continues to sustain in many countries around the globe including Pakistan. This highlights the need to ..., Abstract
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ZIKV infection can cause other severe neurological disorders, such as Guillain-Barré syndrome. Currently, more than 70 countries have reported Zika virus (ZIKV) infections, making it a global public health issue. However, there is no clinically approved vaccine available. Flaviviruses often show ..., Abstract
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In the 2016–2017 winter season, a GII.P16-GII.2 norovirus that had previously been rarely detected was responsible for a majority of the outbreaks of gastroenteritis in China and other countries. Another GII.2 virus, GII.P2-GII.2, had been rarely reported as a cause of gastroenteritis outbreaks ..., Abstract
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