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Virologica Sinica, 34 (1) : 50, 2019
Research Article
Molecular Epidemiology of Echovirus 18 Circulating in Mainland China from 2015 to 2016
1 Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Virology Laboratory, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China
2 WHO WPRO Regional Polio Reference Laboratory and Key Laboratory of Medical Virology and Viral Diseases, National Health and Family Planning Commission of China, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
 Correspondence: wenbo_xu1@aliyun.com;xiezhengde@bch.com.cn
(1178.37KB)  (203.93KB)  
Abstract
Echovirus 18 (E18), a serotype of Enterovirus B (EV-B) species, is an important pathogen in aseptic meningitis. E18 has rarely been detected in mainland China, but became the predominant pathogen associated with viral encephalitis (VE) and meningitis in Hebei province for the first time in 2015. To investigate the molecular epidemiology and genetic characteristics of the E18 in China, sixteen E18 strains from patients with hand, foot, and mouth disease (HFMD) in six provinces of China between 2015 and 2016, with four E18 strains isolated from patients with VE in Hebei Province in 2015 were obtained and sequenced. Combined with the sequences from the GenBank database, we performed an extensive genetic analysis. Phylogenetic analysis of VP1 gene sequences revealed that all E18 strains from mainland China after 2015 belonged to subgenotype C2. There were no obvious specific differences in phylogenetic and variation analyses of E18 genome sequences between HFMD and viral encephalitis/meningitis strains. Potential multiple recombination may have occurred in the 5′-untranslated region and in the P2 and P3 nonstructural protein-encoding regions of E18 strains from China. The current E18 strains were potential multiple-recombinant viruses. Overall, these findings supported that E18 caused HFMD, viral encephalitis, and meningitis, although there were no significant associations between clinical features and viral genomic characteristics.
Received: 23 Aug 2018  Accepted: 26 Nov 2018  Published online: 21 Feb 2019
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