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Virologica Sinica, 34 (1) : 102, 2019
Pathogenic Characterization and Full Length Genome Sequence of a Reassortant Infectious Bursal Disease Virus Newly Isolated in Pakistan
1. Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, the Chinese Academy of Agricultural Sciences, Harbin 150069, China
2. OIE Reference Laboratory for Infectious Bursal Disease, Harbin 150069, China
3. Jiangsu Co-innovation Centre for Prevention and Control of Important Animal Infectious Disease and Zoonoses, Yangzhou 225009, China
4. Pathology Department, University of Veterinary and Animal Sciences, Lahore 54660, Pakistan
5. Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YG, United Kingdom
6. Department of Pathology, College of Veterinary Medicine, University of Georgia, Atlanta 30602, USA
 Correspondence: wangxiaomei@caas.cn;qixiaole@caas.cn
(760.61KB)  (108.90KB)  
Infectious bursal disease (IBD), caused by IBD virus (IBDV), is one of the most devastating diseases of the poultry. Despite the use of mass- and intense-vaccination regimens, the disease continues to sustain in many countries around the globe including Pakistan. This highlights the need to ascertain the characterization of field circulating strains at resolution that provides evidences of vaccine failures. In this study, a naturally occurring reassortant IBDV (referred as PK2) was identified and for the first time the full-genomic and pathogenic characterization of Pakistan strain was revealed. Genome analysis showed that the segment A of PK2 was derived from a very virulent IBDV (vvIBDV) whereas the segment B was acquired from another unique ancestor. Furthermore, infection of SPF chickens with PK2 revealed the potential of the virus in causing infection and inducing pathologies. Taken together, the present study provides useful data for further understanding of the popular and evolution of IBDV, which will helpfully support a better prevention and control of the disease in Pakistan.
Received: 31 Jul 2018  Accepted: 28 Nov 2018  Published online: 6 Feb 2019
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