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Author [刘畅] article list of Virologica Sinica
Despite the success of combined antiretroviral therapy in recent years, the prevalence of human immunodeficiency virus (HIV)-associated neurocognitive disorders in people living with HIV-1 is increasing, significantly reducing the health-related quality of their lives. Although neurons cannot be ..., Abstract
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In conclusion,we first found that HIV infection upregulates the ATL1 mRNA.Up-regulation of ATL1 contributes to HIV-1 replication and down-regulation of ATL1 in host cells inhibited the viral replication.The further research found that ATL1 promoted the level of Env expression on the cell surface ..., Abstract
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The multifunctional trans-activator Tat is an essential regulatory protein for HIV-1 replication and is characterized by high sequence diversity. Numerous experimental studies have examined Tat in HIV-1 subtype B, but research on subtype C Tat is lacking, despite the high prevalence ..., Abstract
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Perinatal transmission of Human immunodeficiency virus (HIV), also called mother-to-child transmission (MTCT), accounts for 90% of infections in infants worldwide and occurs in 30%-45% of children born to untreated HIV-1 infected mothers. Among HIV-1 infected mothers, some viruses are transmitted ..., Abstract
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In order to quantitate the bovine immunodeficiency virus (BIV) infection in vitro, a BIV indicator cell line (BIVL) was established by transfecting baby hamster kidney cells with reporter plasmids containing the firefly luciferase gene driven by a BIV long terminal repeat promoter. The BIV ..., Abstract
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A outbreak of disease with symptoms of evisceration and skin ulteration led to mass mortality in sea cucumber Apostichopus japonicus cultivated in indoor ponds near the Dalian coast from December 2004 to April 2005. Spherical virus particles with a diameter of 75-200 nm were found in the cytoplasm ..., Abstract
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SHIV (SIV/HIV chimeric virus) proviral DNA carrying Human immunodeficiency (virus) type1 (HIV-1 HXBc2) capsid was constructed on the backbone of Simian immunodeficiency (virus) (SIVmm239). The gene expression of chimeric virus could be detected in 293T cells transfected by SHIV proviral DNA. ..., Abstract
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The matrix and the capsid are main structural proteins of Bovine immunodeficency virus (BIV) and play important roles in virus life cycle. In order to analyze these two proteins in vitro, we cloned these two genes into the prokaryotic expression vector pTXB and expressed in E. coli BL21(DE3) in a ..., Abstract
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