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Author [李晓] article list of Virologica Sinica
The chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus, which has infected millions of people in Africa, Asia, Americas, and Europe since it reemerged in India and Indian Ocean regions in 2005–2006. Starting in the middle of November 2016, CHIKV has been widely spread, and more than ..., Abstract
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Coxsackievirus A16 (CA16) is one of the major causes of hand, foot, and mouth disease (HFMD) worldwide, which is a common illness that affects children. The frequent occurrence of HFMD outbreaks has become a serious public health problem in Asia. Therefore, it is important to understand the ..., Abstract
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Although IL-12 plays a critical role in priming Th1 and cytotoxic T lymphocyte (CTL) responses, Toll-like receptor (TLR) signaling only induces low amounts of IL-12 in dendritic cells and macrophages, implying the existence of stringent regulatory mechanisms. In this study, we sought to uncover ..., Abstract
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Paramyxovirus Tianjin strain, a new genotype of Sendai virus, was isolated from the lungs of common cotton-eared marmoset that died of severe respiratory infection in the marmoset colonies. The 19.28% IgM positive rate in the young children with acute respiratory tract infection suggested a close ..., Abstract
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The amino acid sequences of the NP, P, M, F, HN and L proteins of the paramyxovirus Tianjin strain were analyzed by using the bioinformatics methods. Phylogenetic analysis based on 6 structural proteins among the Tianjin strain and 25 paramyxoviruses showed that the Tianjin strain belonged to the ..., Abstract
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Three pairs of primers P1/P2, P3/P4 and P5/P6 of porcine circovirus 2 were designed and synthesized to compare the sensitivity and specialization to amplify products of 404bp, 647bp and 1773 bp. Optimum dilution of PK15 cell genome infected with PCV 2 was achieved with 10-6ng, 10-5ng to yield from ..., Abstract
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According to the published genomic sequence of Porcine circovirus(PCV2), a pair of specific primers was designed to amplify the complete genome of PCV2 from tissues of piglets with PMWS. Five complete genomes of PCV2, named Fujian PCV, Guangxi PCV, Hainan PCV, Hunan PCV and Shandong PCV, were ..., Abstract
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The pregenomic RNA, serves as a template for reverse transcription and encodes the reverse transcriptase for Hepatitis B virus (HBV) replication, has the energetically flexible secondary and tertiary structures, which may reduce the accessibility of ribozyme. To identify accessible target sites for ..., Abstract
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Abstract:As the close consan guinity of human race,the common cotton—eared marmoset(Callithrbc
Jacchus)has been used in a wide range of research as a primate mode1.Acute respiratory infection(ARI)
broke out in a colony reared in the experimental animal center of Tianjin Medical ..., Abstract
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The present is aimed at identifying the activation of TRAFs in nasopharyngeal carcinoma
(NPC)ill"oitro The differentia1 expression of TRAF2、TRAF3 was not detected in RNA and protein
1evel,whereas the expression of TRAF1 in HNE2一LM P1 eel1 1ines was much more abundant than that
in ..., Abstract
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Out of 33 neonates with acute gastroenteritis, 12(36.4%) were detected tohave virus-like ..., Abstract
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