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Author [1] article list of Virologica Sinica
Cyclophilin A (CypA) is a peptidyl-prolyl cis/trans isomerase that interacts with the matrix protein (M1) of influenza A virus (IAV) and restricts virus replication by regulating the ubiquitin–proteasome-mediated degradation of M1. However, the mechanism by which CypA regulates M1 ..., Abstract
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Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a zoonotic pathogen capable of causing severe respiratory disease in humans. Although dromedary camels are considered as a major reservoir host, the MERS-CoV infection dynamics in camels are not fully understood. Through surveillance in ..., Abstract
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Seneca Valley virus (SVV), a newly determined etiological agent of vesicular disease in swine, causes porcine idiopathic disease and occasional acute death in piglets. Recently, an increased number of SVV infection cases have been reported in the United States (US) and China, resulting in ..., Abstract
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Natural killer (NK) cells play an important role in innate immunity to hepatitis C virus (HCV), especially in response to HCV infections. Killer cell immunoglobulin-like receptors (KIRs) are the primary receptors of NK cells that regulate NK cell behavior to antivirus infection response. Our aim ..., Abstract
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The Cyclophragma undans nucleopolyhedrovirus (CyunNPV), a potential pest control agent, was isolated from Cyclophragma undans (Lepidoptera: Lasiocampidae), an important forest pest. In the present study, we performed detailed genome analysis of CyunNPV and compared its genome to those of ..., Abstract
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Yunnan is one of the worst hit regions by HIV/AIDS in China. In last decade, Yunnan has made great achievements in prevention and control of HIV/AIDS. However, Yunnan has a large number of non-Chinese immigrants. HIV prevalence and spreading in this risk population is a huge challenge for Yunnan to ..., Abstract
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The establishment of highly sensitive diagnostic methods is critical in the early diagnosis and control of Zika virus (ZIKV) and in preventing serious neurological complications of ZIKV infection. In this study, we established micro-droplet digital polymerase chain reaction (ddPCR) and real-time ..., Abstract
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Rabies is one of the most dangerous and widespread zoonosis and is characterized by severe neurological signs and a high case-mortality rate of nearly 100%. Vaccination is the most effective way to prevent rabies in humans and animals. In this study, the relationship between exhaustive exercise and ..., Abstract
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Oncolytic measles virus (OMV) is a promising antitumor agent. However, the presence of anti-measles neutralizing antibodies (NAbs) against the hemagglutinin (H) protein of OMV is a major barrier to the therapeutic application of OMV in clinical practice. In order to overcome this challenge ..., Abstract
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Little data is available on the evaluation of the occurrence rates of Epstein-Barr virus (EBV) in saliva and relationship with highly active antiretroviral therapy (HAART) use in HIV/AIDS patients in China. We conducted a retrospective cohort study of EBV serological tests for HIV/AIDS patients ..., Abstract
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Suzhou is experiencing a dynamic human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) epidemic. While serology based surveillance systems have reported the spread of HIV/AIDS, detailed tracking of its molecular epidemiology and transmission in populations remains mostly ..., Abstract
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It is known that vaccine-induced antibodies can aggravate the infections by the antibody-dependent enhancement (ADE) in some cases. Vaccine-induced enhancement of susceptibility to severe acute respiratory syndrome coronavirus (SARS-CoV) has also been documented. We have previously reported that an ..., Abstract
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Effective oral infection is set off by interaction of a group of conserved per os infectivity factors (PIFs) with larval midgut columnar epithelial cells. We constructed pseudotyped viruses by substituting pif1, pif2 or pif3 genes of Helicoverpa armigera nucleopolyhedrovirus ..., Abstract
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Porcine circoviruses (PCV) include PCV1, PCV2, and the new-emerging PCV3. PCV2 is pathogenic to pigs, but the pathogenicity of PCV3 in pigs is debatable. Recently, there have been frequent reports of PCV2 and PCV3 co-infections in clinical samples. Thus, it would be practical to develop a duplex ..., Abstract
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Wheat dwarf disease caused by wheat dwarf virus (WDV) is currently present in wheat growing regions in China and causes serious losses in wheat yield. To develop reliable and effective serological detection methods for WDV, the coat protein (CP) gene of WDV was cloned and expressed in ..., Abstract
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Hepatitis B virus (HBV) infection is one of the major problems that threatens global health. There have been many studies on HBV, but the relationship between HBV and host factors is largely unexplored and more studies are needed to clarify these interactions. Filamin B is an actin-binding ..., Abstract
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A novel PRRSV strain was isolated in China that was genetically similar to the NADC30 strain which is reported to have spread throughout China. The objective of the present study was to evaluate the cross-protective efficacy of the live vaccine TJM-F92 in young pigs against challenge with a ..., Abstract
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Porcine deltacoronavirus (PDCoV) is a newly identified virus that causes watery diarrhea in newborn piglets and results in significant economic losses to the pig industry. Since first reported in Hong Kong in 2012, PDCoV has been subsequently detected in USA, South Korea, Thailand, and mainland ..., Abstract
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In our previous works, we have reported genetically diverse SARS-related coronaviruses (SARSr-CoV) in a single bat cave, Yunnan province, China, and suggested that some SARSr-CoVs may have high potential to infect humans without the necessity for an intermediate host. In this report, we developed a ..., Abstract
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To better understand the role of wild birds in the emergence and potential dissemination of subtype H7N9 viruses, in late 2015, we collected samples from wild land birds in Hubei province and performed virus isolation as well as full genome sequencing. A novel H7N9 virus was isolated from a ..., Abstract
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