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Author [1] article list of Virologica Sinica
Infectious bursal disease (IBD), caused by IBD virus (IBDV), is one of the most devastating diseases of the poultry. Despite the use of mass- and intense-vaccination regimens, the disease continues to sustain in many countries around the globe including Pakistan. This highlights the need to ..., Abstract
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The avian influenza virus (AIV) H5N7 was first isolated from wild birds in North America in 2001 (Spackman et al., 2007), and information on only 25 strains of this virus has been deposited in the Global Initiative on Sharing All Influenza Data ..., Abstract
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Enterovirus 71 (EV71), a major causative agent of hand, foot, and mouth disease, has caused periodic infection outbreaks in children in the Asia-Pacific region. In order to describe the largely unknown life cycle of EV71, the molecular basis of its virus-host interactions must first be determined. ..., Abstract
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Echovirus 18 (E18), a serotype of Enterovirus B (EV-B) species, is an important pathogen in aseptic meningitis. E18 has rarely been detected in mainland China, but became the predominant pathogen associated with viral encephalitis (VE) and meningitis in Hebei province for the first time in 2015. To ..., Abstract
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An investigation was carried out to test for mink circovirus (MiCV) infection in samples from minks, foxes and raccoon dogs with diarrhea in China. The results demonstrated that the infection rates of MiCV in minks, foxes and raccoon dogs were very high on some fur farms in China. The fox was the ..., Abstract
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RNA virus features the high per-generation mutation rate, and thus usually exists as a population presenting intrahost diversity. By the aids of deep sequencing and bioinformatic techniques, recent studies have provided new insights into viral intrahost evolution and viral-host interaction. ..., Abstract
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Mutations in the polymerase basic 2 (PB2) gene of avian influenza viruses are important signatures for their adaptation to mammalian hosts. Various adaptive mutations have been identified around the 627 and nuclear localization sequence (NLS) domains of PB2 protein, and these mutations ..., Abstract
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Porcine reproductive and respiratory syndrome (PRRS) continues to be one of the most important swine diseases worldwide. Interferon-c (IFNγ)-mediated type I cell-mediated immune response plays an important role in protection from, and clearance of, PRRS virus (PRRSV). Several lymphocyte subsets ..., Abstract
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The development of a vaccine based on human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) that elicits potent protective antibodies against infection has been challenging. Recently, we compared the antibody production patterns of HIV-1 Env gp120 and hepatitis B virus surface ..., Abstract
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Cyclophilin A (CypA) is a peptidyl-prolyl cis/trans isomerase that interacts with the matrix protein (M1) of influenza A virus (IAV) and restricts virus replication by regulating the ubiquitin–proteasome-mediated degradation of M1. However, the mechanism by which CypA regulates M1 ..., Abstract
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Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a zoonotic pathogen capable of causing severe respiratory disease in humans. Although dromedary camels are considered as a major reservoir host, the MERS-CoV infection dynamics in camels are not fully understood. Through surveillance in ..., Abstract
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Seneca Valley virus (SVV), a newly determined etiological agent of vesicular disease in swine, causes porcine idiopathic disease and occasional acute death in piglets. Recently, an increased number of SVV infection cases have been reported in the United States (US) and China, resulting in ..., Abstract
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Natural killer (NK) cells play an important role in innate immunity to hepatitis C virus (HCV), especially in response to HCV infections. Killer cell immunoglobulin-like receptors (KIRs) are the primary receptors of NK cells that regulate NK cell behavior to antivirus infection response. Our aim ..., Abstract
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The Cyclophragma undans nucleopolyhedrovirus (CyunNPV), a potential pest control agent, was isolated from Cyclophragma undans (Lepidoptera: Lasiocampidae), an important forest pest. In the present study, we performed detailed genome analysis of CyunNPV and compared its genome to those of ..., Abstract
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Yunnan is one of the worst hit regions by HIV/AIDS in China. In last decade, Yunnan has made great achievements in prevention and control of HIV/AIDS. However, Yunnan has a large number of non-Chinese immigrants. HIV prevalence and spreading in this risk population is a huge challenge for Yunnan to ..., Abstract
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The establishment of highly sensitive diagnostic methods is critical in the early diagnosis and control of Zika virus (ZIKV) and in preventing serious neurological complications of ZIKV infection. In this study, we established micro-droplet digital polymerase chain reaction (ddPCR) and real-time ..., Abstract
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Rabies is one of the most dangerous and widespread zoonosis and is characterized by severe neurological signs and a high case-mortality rate of nearly 100%. Vaccination is the most effective way to prevent rabies in humans and animals. In this study, the relationship between exhaustive exercise and ..., Abstract
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Oncolytic measles virus (OMV) is a promising antitumor agent. However, the presence of anti-measles neutralizing antibodies (NAbs) against the hemagglutinin (H) protein of OMV is a major barrier to the therapeutic application of OMV in clinical practice. In order to overcome this challenge ..., Abstract
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Little data is available on the evaluation of the occurrence rates of Epstein-Barr virus (EBV) in saliva and relationship with highly active antiretroviral therapy (HAART) use in HIV/AIDS patients in China. We conducted a retrospective cohort study of EBV serological tests for HIV/AIDS patients ..., Abstract
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Suzhou is experiencing a dynamic human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) epidemic. While serology based surveillance systems have reported the spread of HIV/AIDS, detailed tracking of its molecular epidemiology and transmission in populations remains mostly ..., Abstract
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