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Author [Xiaohong Kong] article list of Virologica Sinica
In conclusion,we first found that HIV infection upregulates the ATL1 mRNA.Up-regulation of ATL1 contributes to HIV-1 replication and down-regulation of ATL1 in host cells inhibited the viral replication.The further research found that ATL1 promoted the level of Env expression on the cell surface ..., Abstract
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The multifunctional trans-activator Tat is an essential regulatory protein for HIV-1 replication and is characterized by high sequence diversity. Numerous experimental studies have examined Tat in HIV-1 subtype B, but research on subtype C Tat is lacking, despite the high prevalence ..., Abstract
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In summary, this report documents the generation of antisense transcripts from clone127 of the R29 strain of BIV. An antisense ORF was predicted, and antisense transcripts were detected in 293T cells transfected with DNA containing the BIV127 proviral sequence. More importantly, the antisense ..., Abstract
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The cellular protein tetherin tethers the HIV-1 viral particles on the cellular membrane to inhibit the replication of HIV-1. However, the HIV-1 accessory protein Vpu counteracts the antiviral function of tetherin. In this study, two retroviral vector plasmids were constructed. One inhibited the ..., Abstract
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