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Author [Xinwen Chen] article list of Virologica Sinica
Feasible and effective cell models for hepatitis B virus (HBV) infection are required for investigating the complete lifecycle of this virus,including the early steps of viral entry.Resistance to dimethyl sulfoxide/polyethylene glycol (DMSO/PEG),hNTCP expression,and a differentiated state are the ..., Abstract
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Hepatitis C virus (HCV) infects approximately 180 million people worldwide.Significant progress has been made since the establishment of in vitro HCV infection models in cells. However,the replication of HCV is complex and not completely understood. Here,we found that the expression of host ..., Abstract
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The actin nucleator actin-related protein complex (Arp2/3) is composed of seven subunits: Arp2,Arp3, p40/ARPC1 (P40), p34/ARPC2 (P34), p21/ARPC3 (P21), p20/ARPC4 (P20), and p16/ARPC5(P16). Arp2/3 plays crucial roles in a variety of cellular activities through regulation of actin polymerization. ..., Abstract
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Subgenomic replicons of hepatitis C virus (HCV) have been widely used for studying HCV replication. Here, we report a new subgenomic replicon based on a strain isolated from a chronically infected patient. The coding sequence of HCV was recovered from a Chinese chronic hepatitis C patient ..., Abstract
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The construction of the first infectious clone JFH-1 speeds up the research on hepatitis C virus (HCV). However, Huh7 cell line was the only highly permissive cell line for HCV infection and only a few clones were fully permissive. In this study, two different fully permissive clones of Huh7 cells ..., Abstract
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HBV is the predominant pathogen associated with hepatitis cases in China. Although the HBV replication mechanism has been extensively documented in recent years, the virus entry mechanism remains elusive; in particular, the HBV receptor has yet to be identified. Recently, a research team led by Dr. ..., Abstract
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A 62-year-old man had chronic hepatitis B virus (HBV) infection and was diagnosed with liver cirrhosis. At the time of diagnosis the patient’s virologic markers were positive for hepatitis B surface antigen (HBsAg), antibody to hepatitis B e antigen (anti-HBe) and antibody to hepatitis B core ..., Abstract
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The Baculoviridae are a large family of enveloped DNA viruses exclusively pathogenic to arthropods. Baculoviruses have been extensively used in insect cell-based recombinant protein expression system and as biological pesticides. They have been deomostrated to be safe to mammals, birds and fish. ..., Abstract
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