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Current Issue of Virologica Sinica
Nov Vol. 33, No 5, 2018
Nipah virus (NiV), a zoonotic paramyxovirus belonging to the genus Henipavirus, is classified as a Biosafety Level-4 pathogen based on its high pathogenicity in humans and the lack of available vaccines or therapeutics. Since its initial emergence in 1998 in Malaysia, this virus has been reported in Asia, Africa, and the South Pacific Ocean. NiV has a wide range of hosts, from its natural reservoir Pteropid bats to humans, horses, dogs, cats, cows, and pigs. NiV spreads from bats to humans through two main pathways, intermediate hosts (pigs and horses) and food-borne transmission via date palm sap contaminated with the saliva or urine of fruit bats. In this issue, Sun et al. reviewed the recent studies on the geographical and phylogenetic properties, transmission, and protein structure and function of NiV. The cover image is provided courtesy of Bangyao Sun and Di Liu. (See Page 385-393 for details).
Article List:
Editorial
The Society for Invertebrate Pathology (SIP) is foremost in the world covering all aspects of related research in insect virology, bacteriology, mycology, parasitology and microbial control. The SIP has a wide scientific appeal with members from many countries spanning every continent in the ..., Abstract
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Review
Nipah virus (NiV), a zoonotic paramyxovirus belonging to the genus Henipavirus, is classified as a Biosafety Level-4 pathogen based on its high pathogenicity in humans and the lack of available vaccines or therapeutics. Since its initial emergence in 1998 in Malaysia, this virus has become ..., Abstract
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Research Article
Seneca Valley virus (SVV), a newly determined etiological agent of vesicular disease in swine, causes porcine idiopathic disease and occasional acute death in piglets. Recently, an increased number of SVV infection cases have been reported in the United States (US) and China, resulting in ..., Abstract
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Research Article
Rasmussen's encephalitis (RE) is a rare pediatric neurological disorder, and the exact etiology is not clear. Viral infection may be involved in the pathogenesis of RE, but conflicting results have reported. In this study, we evaluated the expression of both Epstein-Barr virus (EBV) and human ..., Abstract
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Research Article
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a zoonotic pathogen capable of causing severe respiratory disease in humans. Although dromedary camels are considered as a major reservoir host, the MERS-CoV infection dynamics in camels are not fully understood. Through surveillance in ..., Abstract
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Research Article
Histone deacetylase (HDAC) inhibitors show clinical promise for the treatment of cancers, including hepatocellular carcinoma (HCC). In this study, we investigated the effect of HDAC inhibitor treatment on hepatitis C virus (HCV) replication in Huh7 human liver cells and in a mouse model of HCV ..., Abstract
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Research Article
Porcine reproductive and respiratory syndrome virus (PRRSV) is a member within the family Arteriviridae of the order Nidovirales. Replication of this positive-stranded RNA virus within the host cell involves expression of viral replicase proteins encoded by two ORFs, namely ORF1a ..., Abstract
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Research Article
Cyclophilin A (CypA) is a peptidyl-prolyl cis/trans isomerase that interacts with the matrix protein (M1) of influenza A virus (IAV) and restricts virus replication by regulating the ubiquitin–proteasome-mediated degradation of M1. However, the mechanism by which CypA regulates M1 ..., Abstract
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Letter
Marine mammals are widely distributed and can be found almost in all coastal waters and coastlines around the world. The interface areas between marine and terrestrial environments provide natural habitats for aquatic and semiaquatic mammals as well as for reservoir species of avian influenza ..., Abstract
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Letter
Middle East respiratory syndrome coronavirus (MERS-CoV) is a major health concern to the general population, with no available licensed therapeutic or vaccine. Virus-like particles (VLPs) comprise viral structural proteins, which represent a safe and highly immunogenic vaccine delivery platform ..., Abstract
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Perspective
Recent study by Joel Dudley and colleagues published in Neuron on July 11, demonstrated that both HHV-6A and HHV-7 could be key causal contributors to Alzheimer’s disease (AD). However, among various biological and technical issues, we review how complicate to demonstrate the link of HHV-6A ..., Abstract
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Perspective
Hepatitis B virus (HBV) infection remains a great public health problem worldwide. Here, we discuss the rationality and possibility of cellular inhibitor of apoptosis proteins (cIAPs) as a therapeutic target for HBV functional cure, and introduce the ongoing Phase I clinical study of cIAPs ..., Abstract
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