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Current Issue of Virologica Sinica
May Vol. 33, No 2, 2018
Baculoviruses have been used as biocontrol agents against insect pests and also exploited in therapeutic strategies and protein expression. The successful primary infection of baculoviruses in insect host is largely dependent on a family of membrane resident proteins, so-called per os infectivity factors (PIFs), which is likely to play an important role in virus entry into midgut epithelial cells of susceptible insect larvae. In this issue, George Alliwa Makalliwa et al. investigated the functional roles of PIF1, 2, and 3 using PIF-replaced viruses. They found that only PIF3 replacement showed the formation of PIF complex and retained partial oral infectivity, while substitution of either PIF1 or PIF2 inhibited the formation of PIF complex and oral infectivity. These results highlighted that the specificity of PIFs is quite high and the PIF complex is essential for the oral infectivity. The cover is modified from a transmission electron microscopy image of occlusion bodies from PIF3-replaced recombinant Helicoverpa armigera nucleopolyhedrovirus (kindly provided by George Alliwa Makalliwa and Zhihong Hu) with pseudo-color.
Article List:
The cGAS-MITA pathway of cytosolic DNA sensing plays essential roles in immune response against pathogens that contain DNA or with DNA production in their life cycles. The cGAS-MITA pathway also detects leaked or aberrant accumulated self DNA in the cytoplasm under certain pathological ..., Abstract
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An infection by Zika virus (ZIKV), a mosquito-borne flavivirus, broke out in South American regions in 2015, and recently showed a tendency of spreading to North America and even worldwide. ZIKV was first detected in 1947 and only 14 human infection cases were reported until 2007. This virus was ..., Abstract
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Research Article
Porcine deltacoronavirus (PDCoV) is a newly identified virus that causes watery diarrhea in newborn piglets and results in significant economic losses to the pig industry. Since first reported in Hong Kong in 2012, PDCoV has been subsequently detected in USA, South Korea, Thailand, and mainland ..., Abstract
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Research Article
Nullbasic is a mutant form of HIV-1 Tat that has strong ability to protect cells from HIV-1 replication by inhibiting three different steps of viral replication: reverse transcription, Rev export of viral mRNA from the nucleus to the cytoplasm and transcription of viral mRNA by RNA polymerase II. ..., Abstract
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Research Article
A novel PRRSV strain was isolated in China that was genetically similar to the NADC30 strain which is reported to have spread throughout China. The objective of the present study was to evaluate the cross-protective efficacy of the live vaccine TJM-F92 in young pigs against challenge with a ..., Abstract
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Research Article
Hepatitis B virus (HBV) infection is one of the major problems that threatens global health. There have been many studies on HBV, but the relationship between HBV and host factors is largely unexplored and more studies are needed to clarify these interactions. Filamin B is an actin-binding ..., Abstract
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Research Article
Wheat dwarf disease caused by wheat dwarf virus (WDV) is currently present in wheat growing regions in China and causes serious losses in wheat yield. To develop reliable and effective serological detection methods for WDV, the coat protein (CP) gene of WDV was cloned and expressed in ..., Abstract
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Research Article
Porcine circoviruses (PCV) include PCV1, PCV2, and the new-emerging PCV3. PCV2 is pathogenic to pigs, but the pathogenicity of PCV3 in pigs is debatable. Recently, there have been frequent reports of PCV2 and PCV3 co-infections in clinical samples. Thus, it would be practical to develop a duplex ..., Abstract
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Research Article
Effective oral infection is set off by interaction of a group of conserved per os infectivity factors (PIFs) with larval midgut columnar epithelial cells. We constructed pseudotyped viruses by substituting pif1, pif2 or pif3 genes of Helicoverpa armigera nucleopolyhedrovirus ..., Abstract
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Hunting is a common and popular pastime in Portugal. Hunted animals are, generally, for human consumption as meat or local products that are consumed without cooking, increasing the risk of zoonotic transmission of several infectious agents. The present study intended to characterize HEV infection ..., Abstract
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It is known that vaccine-induced antibodies can aggravate the infections by the antibody-dependent enhancement (ADE) in some cases. Vaccine-induced enhancement of susceptibility to severe acute respiratory syndrome coronavirus (SARS-CoV) has also been documented. We have previously reported that an ..., Abstract
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NAP1L1 has been shown to function in the life cycle of several DNA virus and retrovirus. However, whether NAP1L1 regulates hepatitis C virus (HCV), a positive-stranded RNA virus, remain to be elucidated. In this study, we identified NAP1L1 as a novel binding partner for HCV NS3. Our results suggest ..., Abstract
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Suzhou is experiencing a dynamic human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) epidemic. While serology based surveillance systems have reported the spread of HIV/AIDS, detailed tracking of its molecular epidemiology and transmission in populations remains mostly ..., Abstract
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