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Current Issue of Virologica Sinica
Jun Vol. 33, No 3, 2018
The newly emerged mosquito-borne Zika virus (ZIKV) has posed a global threat to human health. Several ZIKV vaccine candidates have been developed, and demonstrated to be efficacious in preclinical studies in mice and nonhuman primates. In this issue, Shiyu Dai et al. report a new virus-like particle (VLP) ZIKV vaccine based on the baculovirus expression system. Those VLPs demonstrate good immunogenicity in immunized mice, as they stimulate high levels of virus neutralizing antibody titers, ZIKV-specific IgG titers and potent memory T cell responses. The cover is adopted from an electron micrograph of negative staining baculovirus-expressed ZIKV VLPs (kindly provided by Fei Deng) with artistic processing. See page 213–226 for details.
Article List:
Research Article
The newly emerged mosquito-borne Zika virus (ZIKV) strains pose a global challenge owing to its ability to cause microcephaly and neurological disorders. Several ZIKV vaccine candidates have been proposed, including inactivated and live attenuated virus vaccines, vector-based vaccines, DNA and ..., Abstract
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Research Article
Little data is available on the evaluation of the occurrence rates of Epstein-Barr virus (EBV) in saliva and relationship with highly active antiretroviral therapy (HAART) use in HIV/AIDS patients in China. We conducted a retrospective cohort study of EBV serological tests for HIV/AIDS patients ..., Abstract
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Research Article
Oncolytic measles virus (OMV) is a promising antitumor agent. However, the presence of anti-measles neutralizing antibodies (NAbs) against the hemagglutinin (H) protein of OMV is a major barrier to the therapeutic application of OMV in clinical practice. In order to overcome this challenge ..., Abstract
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Research Article
Rabies is one of the most dangerous and widespread zoonosis and is characterized by severe neurological signs and a high case-mortality rate of nearly 100%. Vaccination is the most effective way to prevent rabies in humans and animals. In this study, the relationship between exhaustive exercise and ..., Abstract
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Research Article
Porcine reproductive and respiratory syndrome virus (PRRSV) shows characteristic antibody-dependent enhancement (ADE) of infection and causes porcine systemic inflammation, which is similar to a type I allergic reaction; however, the role of porcine FcεRI in ADE is still unclear. In this study ..., Abstract
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Research Article
Despite the success of combined antiretroviral therapy in recent years, the prevalence of human immunodeficiency virus (HIV)-associated neurocognitive disorders in people living with HIV-1 is increasing, significantly reducing the health-related quality of their lives. Although neurons cannot be ..., Abstract
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Research Article
The establishment of highly sensitive diagnostic methods is critical in the early diagnosis and control of Zika virus (ZIKV) and in preventing serious neurological complications of ZIKV infection. In this study, we established micro-droplet digital polymerase chain reaction (ddPCR) and real-time ..., Abstract
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Letter
Enterovirus 71 (EV71) infection causes hand-foot-and-mouth disease (HFMD) in children and might be accompanied by severe neurological complications. It has become one of the most important pathogens of central nervous system infection. To explore the causes of lung injury by EV71, the ..., Abstract
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Letter
The Eurasian avian-like swine influenza A (H1N1) viruses (EAS-H1N1) have circulated in pigs since 1979, and human sporadically infected with EAS-H1N1 have been reported in several countries. In October 2016, the EAS-H1N1 infection in an adult hospitalized patient with severe pneumonia was ..., Abstract
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Letter
Nonenveloped animal viruses must disrupt the host cell membrane to initiate infection. Although myristoylated outer capsid protein is known to be responsible for membrane penetration in nonenveloped viruses, the mechanisms underlying membrane penetration to enter the host cytoplasm remain poorly ..., Abstract
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Perspective
Yunnan is one of the worst hit regions by HIV/AIDS in China. In last decade, Yunnan has made great achievements in prevention and control of HIV/AIDS. However, Yunnan has a large number of non-Chinese immigrants. HIV prevalence and spreading in this risk population is a huge challenge for Yunnan to ..., Abstract
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Correction
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