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Just Accepted Manuscripts Virologica Sinica
Hepatitis B virus (HBV) infection remains a great public health problem worldwide. Here, we discuss the rationality and possibility of cellular inhibitor of apoptosis proteins (cIAPs) as a therapeutic target for HBV functional cure, and introduce the ongoing Phase I clinical study of cIAPs ..., Abstract
Free PDF (252.08KB)  |  Springerlink  |  17 Oct 2018  |  DOI:10.1007/s12250-018-0062-x
Cyclophilin A (CypA) is a peptidyl-prolyl cis/trans isomerase that interacts with the matrix protein (M1) of influenza A virus (IAV) and restricts virus replication by regulating the ubiquitin-proteasome-mediated degradation of M1. However, the mechanism by which CypA regulates M1 ..., Abstract
Free PDF (1348.15KB)  |  Springerlink  |  16 Oct 2018  |  DOI:10.1007/s12250-018-0058-6
Seneca Valley virus (SVV), a newly determined etiological agent of vesicular disease in swine, causes porcine idiopathic disease and occasional acute death in piglets. Recently, an increased number of SVV infection cases have been reported in the United States (US) and China, resulting in ..., Abstract
Free PDF (1354.02KB)  |  Springerlink  |  16 Oct 2018  |  DOI:10.1007/s12250-018-0056-8
Nipah virus (NiV), a zoonotic paramyxovirus belonging to the genus Henipavirus, is classified as a Biosafety Level-4 pathogen based on its high pathogenicity in humans and the lack of available vaccines or therapeutics. Since its initial emergence in 1998 in Malaysia, this virus has become ..., Abstract
Free PDF (2851.88KB)  |  Springerlink  |  11 Oct 2018  |  DOI:10.1007/s12250-018-0050-1
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a zoonotic pathogen capable of causing severe respiratory disease in humans. Although dromedary camels are considered as a major reservoir host, the MERS-CoV infection dynamics in camels are not fully understood. Through surveillance in ..., Abstract
Free PDF (926.88KB)  |  Springerlink  |  11 Oct 2018  |  DOI:10.1007/s12250-018-0051-0
Recent study by Joel Dudley and colleagues published in Neuron on July 11, demonstrated that both HHV-6A and HHV-7 could be key causal contributors to Alzheimer's disease (AD). However, among various biological and technical issues, we review how complicate to demonstrate the link of HHV-6A ..., Abstract
Free PDF (457.04KB)  |  Springerlink  |  17 Sep 2018  |  DOI:10.1007/s12250-018-0049-7
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